Micro cell vesicle technology (mCVT): A novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Yi Hsuan Ou, Shui Zou, Wei Jiang Goh, Suet Yen Chong, Gopalakrishnan Venkatesan, Matthias G. Wacker, Gerrit Storm, Bertrand Czarny, Giorgia Pastorin, Esther C.Y. Woon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

A hybrid gene delivery platform, micro Cell Vesicle Technology (mCVT), produced from the fusion of plasma membranes and cationic lipids, is presently used to improve the transfection efficiency of hard-to-transfect (HTT) cells. The plasma membrane components of mCVTs impart specificity in cellular uptake and reduce cytotoxicity in the transfection process, while the cationic lipids complex with the genetic material and provide structural integrity to mCVTs. This journal is

Original languageEnglish
Pages (from-to)18022-18030
Number of pages9
JournalNanoscale
Volume12
Issue number35
DOIs
Publication statusPublished - 21 Sep 2020

Fingerprint

Dive into the research topics of 'Micro cell vesicle technology (mCVT): A novel hybrid system of gene delivery for hard-to-transfect (HTT) cells'. Together they form a unique fingerprint.

Cite this