Micro-computed tomographic assessment following extremely oversized partial postdilatation of drug-eluting stents

Mounir W.Z. Basalus, K. Gert van Houwelingen, Marc J.K. Ankoné, Jan Feijen, Clemens von Birgelen

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)
46 Downloads (Pure)

Abstract

AIMS: To assess the spatial geometry of drug-eluting stents (DES) following extremely oversized proximal postdilatation. Interventions of distal left main (LM) disease generally require stenting across the LM bifurcation with inherent vessel tapering along this segment and a high likelihood of stent malapposition, which can be avoided by such postdilations.

METHODS AND RESULTS: Sixteen DES (four 3.5 mm-samples of Cypher Select Plus, Taxus Liberté, Endeavor Resolute, Xience V) were deployed in water; 12 samples were then proximally postdilated with noncompliant 5.0 mm balloons at 18 atm. All samples were examined by micro-computed tomography. Taxus Liberté, Endeavor Resolute, and Xience V, showed increased cell areas in the transitional region (just distal to postdilated region), while Cypher Select showed its largest cells inside the postdilated region. Overall, the largest maximum cell area was observed in Endeavor Resolute, while Cypher Select showed the smallest (p<0.001, for both). In addition, the size of the very proximal postdilated cells was relatively small in most DES except Xience V.

CONCLUSIONS: Extremely oversized partial stent postdilatation demonstrated significant between-DES differences in final spatial stent configuration and maximum cell size. These data could be of practical interest with regard to coronary interventions in LM stems with stenting across the LM bifurcation.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalEuroIntervention
Volume6
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • METIS-269202
  • Drug-eluting stent(s)
  • Micro-computed tomography
  • Percutaneous Coronary Intervention (PCI)
  • Oversized postdilation
  • Coronary artery disease
  • Open-cell design
  • Closed-cell design

Fingerprint Dive into the research topics of 'Micro-computed tomographic assessment following extremely oversized partial postdilatation of drug-eluting stents'. Together they form a unique fingerprint.

Cite this