Microbubble spectroscopy of ultrasound contrast agents

Sander M. van der Meer, Benjamin Dollet, Marco M. Voormolen, Chien T. Chin, Ayache Bouakaz, Nico de Jong, Michel Versluis, Detlef Lohse

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309 Citations (Scopus)
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A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.
Original languageEnglish
Pages (from-to)648-656
Number of pages9
JournalThe Journal of the Acoustical Society of America
Issue number1
Publication statusPublished - 2007


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