Microbubble spectroscopy of ultrasound contrast agents

Sander M. van der Meer; Benjamin Dollet; Marco M. Voormolen; Chien T. Chin; Ayache Bouakaz; Nico de Jong; Michel Versluis; Detlef Lohse

doi:10.1121/1.2390673

Microbubble spectroscopy of ultrasound contrast agents

Sander M. van der Meer, Benjamin Dollet, Marco M. Voormolen, Chien T. Chin, Ayache Bouakaz, Nico de Jong, Michel Versluis, Detlef Lohse

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Abstract

A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.

Original language	English
Pages (from-to)	648-656
Number of pages	9
Journal	The Journal of the Acoustical Society of America
Volume	121
Issue number	1
DOIs	https://doi.org/10.1121/1.2390673
Publication status	Published - 2007

Keywords

2023 OA procedure

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10.1121/1.2390673

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title = "Microbubble spectroscopy of ultrasound contrast agents",

abstract = "A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.",

keywords = "2023 OA procedure",

author = "{van der Meer}, {Sander M.} and Benjamin Dollet and Voormolen, {Marco M.} and Chin, {Chien T.} and Ayache Bouakaz and {de Jong}, Nico and Michel Versluis and Detlef Lohse",

year = "2007",

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language = "English",

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T1 - Microbubble spectroscopy of ultrasound contrast agents

AU - van der Meer, Sander M.

AU - Dollet, Benjamin

AU - Voormolen, Marco M.

AU - Chin, Chien T.

AU - Bouakaz, Ayache

AU - de Jong, Nico

AU - Versluis, Michel

AU - Lohse, Detlef

PY - 2007

Y1 - 2007

N2 - A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.

AB - A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.

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U2 - 10.1121/1.2390673

DO - 10.1121/1.2390673

M3 - Article

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VL - 121

SP - 648

EP - 656

JO - The Journal of the Acoustical Society of America

JF - The Journal of the Acoustical Society of America

IS - 1

ER -

Microbubble spectroscopy of ultrasound contrast agents

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