Microbubble spectroscopy of ultrasound contrast agents

Sandeer van der Meer, Benjamin Dollet, Chien T. Chin, Ayache Bouakaz, Marco Voormolen, Nico de Jong, Michel Versluis, Detlef Lohse

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We present a new optical characterization of the behavior of single ultrasound contrast bubbles. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency and recording movies of the bubble response up to 25 million frames per second with an ultra-high-speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables one to reconstruct a resonance curve of the oscillating bubble in a single run. We analyze the data through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantitative agreement with previously reported values. The shell viscosity decreases significantly with the dilatation rate, revealing the nonlinear behavior of the phospholipid coating.
Original languageEnglish
Pages (from-to)3327-3327
JournalThe Journal of the Acoustical Society of America
Issue number5, Suppl
Publication statusPublished - 2006
Event4th Joint Meeting of the Acoustical Society of America and the Acoustical Society of Japan 2006 - Honolulu, United States
Duration: 28 Nov 20062 Dec 2006
Conference number: 4


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