Abstract
Ultrasound contrast microbubbles have the ability to enhance cell permeability and thus may be used as a new way to deliver drugs inter-vascular. It facilitates the transfer of extracellular molecules into cells through ultrasound-activated microbubbles. The present study is designed to correlate the relationship between microbubble induced cell deformation and enhanced cell membrane permeability. Propidium Iodide was used as a membrane integrity probe. Using high-speed imaging of vibrating microbubbles against endothelial cells and imaging transport of Propidium Iodide into these cells showed a direct correlation between cell deformation and resulting cell membrane permeability. The membrane permeabilization lasted for a short period without affecting aortic endothelial cells viability. We identified that microbubbles are crucial to enhance transient cell membrane permeability.
Original language | English |
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Title of host publication | THERAPEUTIC ULTRASOUND |
Subtitle of host publication | 5th International Symposium on Therapeutic Ultrasound |
Pages | 24-28 |
Number of pages | 5 |
DOIs | |
Publication status | Published - 8 May 2006 |
Event | 5th International Symposium on Therapeutic Ultrasound, ISTU 2005 - Boston, United States Duration: 27 Oct 2005 → 29 Oct 2005 Conference number: 5 |
Publication series
Name | AIP Conference Proceedings |
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Volume | 829 |
ISSN (Print) | 0094-243X |
ISSN (Electronic) | 1551-7616 |
Conference
Conference | 5th International Symposium on Therapeutic Ultrasound, ISTU 2005 |
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Abbreviated title | ISTU |
Country/Territory | United States |
City | Boston |
Period | 27/10/05 → 29/10/05 |