Microbubbles reforming endothelium

Annemieke Van Wamel*, Klazina Kooiman, Miranda Harteveld, Marcia Emmer, Folkert J. Ten Cate, Michel Versluis, Nico De Jong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Ultrasound contrast microbubbles have the ability to enhance cell permeability and thus may be used as a new way to deliver drugs inter-vascular. It facilitates the transfer of extracellular molecules into cells through ultrasound-activated microbubbles. The present study is designed to correlate the relationship between microbubble induced cell deformation and enhanced cell membrane permeability. Propidium Iodide was used as a membrane integrity probe. Using high-speed imaging of vibrating microbubbles against endothelial cells and imaging transport of Propidium Iodide into these cells showed a direct correlation between cell deformation and resulting cell membrane permeability. The membrane permeabilization lasted for a short period without affecting aortic endothelial cells viability. We identified that microbubbles are crucial to enhance transient cell membrane permeability.

Original languageEnglish
Title of host publicationTHERAPEUTIC ULTRASOUND
Subtitle of host publication5th International Symposium on Therapeutic Ultrasound
Number of pages5
Publication statusPublished - 8 May 2006
Event5th International Symposium on Therapeutic Ultrasound, ISTU 2005 - Boston, United States
Duration: 27 Oct 200529 Oct 2005
Conference number: 5

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference5th International Symposium on Therapeutic Ultrasound, ISTU 2005
Abbreviated titleISTU
Country/TerritoryUnited States


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