Abstract
We present a microfluidic device for creating defined neural microcircuits by directional axon guidance of two distinct neuron populations. Directional guiding is achieved by a modified version of the 'stomach' shape developed by Forró [1], and two different cell population are made possible by a multilayer silicon-glass construction. Preliminary experiments were conducted by culturing neurons for 2 weeks, with fluorescent microscopy suggesting directional network formation based on two distinct neuron populations. This opens a wide range of possibilities in creating a platform for biological models of more advanced neural microcircuits consisting of distinct cell lines and neuronal subtypes.
| Original language | English |
|---|---|
| Title of host publication | 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 |
| Publisher | IEEE |
| Pages | 2169-2172 |
| Number of pages | 4 |
| ISBN (Electronic) | 978-4-88686-435-2 |
| ISBN (Print) | 979-8-3503-3302-2 |
| Publication status | Published - 7 May 2024 |
| Event | 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 - Kyoto, Japan Duration: 25 Jun 2023 → 29 Jun 2023 Conference number: 22 |
Publication series
| Name | |
|---|---|
| ISSN (Print) | 2167-0013 |
| ISSN (Electronic) | 2167-0021 |
Conference
| Conference | 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 |
|---|---|
| Abbreviated title | Transducers 2023 |
| Country/Territory | Japan |
| City | Kyoto |
| Period | 25/06/23 → 29/06/23 |
Keywords
- 2024 OA procedure
- Convergent
- Directional
- Glass
- Microcircuit
- Microfluidic
- Network
- Neuron
- Silicon
- SOI
- Axon guiding