Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach

N.C. Rivron; Severine le Gac; E.J. Vrij; Jeroen Rouwkema; Daniël Wijnperle; R.K. Truckenmüller; Albert van den Berg; Clemens van Blitterswijk

Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach

N.C. Rivron, Severine le Gac, E.J. Vrij, Jeroen Rouwkema, Daniël Wijnperle, R.K. Truckenmüller, Albert van den Berg, Clemens van Blitterswijk

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Downloads (Pure)

Abstract

Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

Original language	English
Title of host publication	Micro Total Analysis Systems 2009
Editors	Tae Song Kim, Yoon-Sik Lee, Taek-Dong Chung, Noo Li Jeon, Sang-Hoon Lee, Kahp-Yang Suh, Jaebm Choo, Yong-Kweon Kim
Place of Publication	San Diego
Publisher	Chemical and Biological Society
Pages	9-11
Number of pages	3
ISBN (Print)	978-0-9798064-2-1
Publication status	Published - 1 Nov 2009
Event	13th International Conference on Micro Total Analysis Systems, µTAS 2009 - Jeju Island, Korea, Republic of Duration: 1 Nov 2009 → 5 Nov 2009 Conference number: 13

Publication series

Name	microTAS 2009
Publisher	Chemical and Biological Society
Volume	1

Conference

Conference	13th International Conference on Micro Total Analysis Systems, µTAS 2009
Abbreviated title	MicroTAS
Country/Territory	Korea, Republic of
City	Jeju Island
Period	1/11/09 → 5/11/09

Keywords

EWI-17031
IR-69347
microwell array
Self-Assembly
vasculogenesis
Tissue Engineering
METIS-264257

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://eprints.eemcs.utwente.nl/secure2/17031/01/proceedings_605022.pdf

Cite this

Rivron, N. C., le Gac, S., Vrij, E. J., Rouwkema, J., Wijnperle, D., Truckenmüller, R. K., van den Berg, A., & van Blitterswijk, C. (2009). Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach. In T. S. Kim, Y.-S. Lee, T.-D. Chung, N. L. Jeon, S.-H. Lee, K.-Y. Suh, J. Choo, & Y.-K. Kim (Eds.), Micro Total Analysis Systems 2009 (pp. 9-11). (microTAS 2009; Vol. 1). Chemical and Biological Society. http://eprints.eemcs.utwente.nl/secure2/17031/01/proceedings_605022.pdf

Rivron, N.C. ; le Gac, Severine ; Vrij, E.J. et al. / Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach. Micro Total Analysis Systems 2009. editor / Tae Song Kim ; Yoon-Sik Lee ; Taek-Dong Chung ; Noo Li Jeon ; Sang-Hoon Lee ; Kahp-Yang Suh ; Jaebm Choo ; Yong-Kweon Kim. San Diego : Chemical and Biological Society, 2009. pp. 9-11 (microTAS 2009).

@inproceedings{c4fe74c017d74f0cbfa12cfe511e108d,

title = "Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach",

abstract = "Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.",

keywords = "EWI-17031, IR-69347, microwell array, Self-Assembly, vasculogenesis, Tissue Engineering, METIS-264257",

author = "N.C. Rivron and {le Gac}, Severine and E.J. Vrij and Jeroen Rouwkema and Dani{\"e}l Wijnperle and R.K. Truckenm{\"u}ller and {van den Berg}, Albert and {van Blitterswijk}, Clemens",

year = "2009",

month = nov,

day = "1",

language = "English",

isbn = "978-0-9798064-2-1",

series = "microTAS 2009",

publisher = "Chemical and Biological Society",

pages = "9--11",

editor = "Kim, {Tae Song} and Yoon-Sik Lee and Taek-Dong Chung and Jeon, {Noo Li} and Sang-Hoon Lee and Kahp-Yang Suh and Jaebm Choo and Yong-Kweon Kim",

booktitle = "Micro Total Analysis Systems 2009",

note = "13th International Conference on Micro Total Analysis Systems, µTAS 2009, MicroTAS ; Conference date: 01-11-2009 Through 05-11-2009",

}

Rivron, NC, le Gac, S, Vrij, EJ, Rouwkema, J , Wijnperle, D, Truckenmüller, RK, van den Berg, A & van Blitterswijk, C 2009, Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach. in TS Kim, Y-S Lee, T-D Chung, NL Jeon, S-H Lee, K-Y Suh, J Choo & Y-K Kim (eds), Micro Total Analysis Systems 2009. microTAS 2009, vol. 1, Chemical and Biological Society, San Diego, pp. 9-11, 13th International Conference on Micro Total Analysis Systems, µTAS 2009, Jeju Island, Korea, Republic of, 1/11/09. <http://eprints.eemcs.utwente.nl/secure2/17031/01/proceedings_605022.pdf>

Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach. / Rivron, N.C.; le Gac, Severine; Vrij, E.J. et al.
Micro Total Analysis Systems 2009. ed. / Tae Song Kim; Yoon-Sik Lee; Taek-Dong Chung; Noo Li Jeon; Sang-Hoon Lee; Kahp-Yang Suh; Jaebm Choo; Yong-Kweon Kim. San Diego: Chemical and Biological Society, 2009. p. 9-11 (microTAS 2009; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach

AU - Rivron, N.C.

AU - le Gac, Severine

AU - Vrij, E.J.

AU - Rouwkema, Jeroen

AU - Wijnperle, Daniël

AU - Truckenmüller, R.K.

AU - van den Berg, Albert

AU - van Blitterswijk, Clemens

N1 - Conference code: 13

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

AB - Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

KW - EWI-17031

KW - IR-69347

KW - microwell array

KW - Self-Assembly

KW - vasculogenesis

KW - Tissue Engineering

KW - METIS-264257

M3 - Conference contribution

SN - 978-0-9798064-2-1

T3 - microTAS 2009

SP - 9

EP - 11

BT - Micro Total Analysis Systems 2009

A2 - Kim, Tae Song

A2 - Lee, Yoon-Sik

A2 - Chung, Taek-Dong

A2 - Jeon, Noo Li

A2 - Lee, Sang-Hoon

A2 - Suh, Kahp-Yang

A2 - Choo, Jaebm

A2 - Kim, Yong-Kweon

PB - Chemical and Biological Society

CY - San Diego

T2 - 13th International Conference on Micro Total Analysis Systems, µTAS 2009

Y2 - 1 November 2009 through 5 November 2009

ER -

Rivron NC, le Gac S, Vrij EJ, Rouwkema J , Wijnperle D, Truckenmüller RK et al. Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach. In Kim TS, Lee YS, Chung TD, Jeon NL, Lee SH, Suh KY, Choo J, Kim YK, editors, Micro Total Analysis Systems 2009. San Diego: Chemical and Biological Society. 2009. p. 9-11. (microTAS 2009).

Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach

Abstract

Publication series

Conference

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this