Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach

N.C. Rivron, Severine le Gac, E.J. Vrij, Jeroen Rouwkema, Daniël Wijnperle, R.K. Truckenmüller, Albert van den Berg, Clemens van Blitterswijk

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.
Original languageEnglish
Title of host publicationMicro Total Analysis Systems 2009
EditorsTae Song Kim, Yoon-Sik Lee, Taek-Dong Chung, Noo Li Jeon, Sang-Hoon Lee, Kahp-Yang Suh, Jaebm Choo, Yong-Kweon Kim
Place of PublicationSan Diego
PublisherChemical and Biological Society
Pages9-11
Number of pages3
ISBN (Print)978-0-9798064-2-1
Publication statusPublished - 1 Nov 2009
Event13th International Conference on Micro Total Analysis Systems, µTAS 2009 - Jeju Island, Korea, Republic of
Duration: 1 Nov 20095 Nov 2009
Conference number: 13

Publication series

NamemicroTAS 2009
PublisherChemical and Biological Society
Volume1

Conference

Conference13th International Conference on Micro Total Analysis Systems, µTAS 2009
Abbreviated titleMicroTAS
CountryKorea, Republic of
CityJeju Island
Period1/11/095/11/09

Keywords

  • EWI-17031
  • IR-69347
  • microwell array
  • Self-Assembly
  • vasculogenesis
  • Tissue Engineering
  • METIS-264257

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