Abstract
Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.
Original language | English |
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Title of host publication | Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
Publisher | The Chemical and Biological Microsystems Society |
Pages | 9-11 |
Number of pages | 3 |
ISBN (Print) | 9780979806421 |
Publication status | Published - 1 Jan 2009 |
Event | 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009 - Jeju, Korea, Republic of Duration: 1 Nov 2009 → 5 Nov 2009 Conference number: 13 |
Conference
Conference | 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009 |
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Abbreviated title | MicroTAS |
Country/Territory | Korea, Republic of |
City | Jeju |
Period | 1/11/09 → 5/11/09 |
Keywords
- Microwell array
- Self-assembly
- Tissue engineering
- Vasculogenesis