Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach

N. C. Rivron; S. Le Gac; E. Vrij; J. Rouwkema; D. Wijnperlé; R. Truckenmuller; A. Van Den Berg; C. A. Van Blitterswijk

Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach

N. C. Rivron, S. Le Gac, E. Vrij, J. Rouwkema, D. Wijnperlé, R. Truckenmuller, A. Van Den Berg, C. A. Van Blitterswijk

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

Original language	English
Title of host publication	Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	The Chemical and Biological Microsystems Society
Pages	9-11
Number of pages	3
ISBN (Print)	9780979806421
Publication status	Published - 1 Jan 2009
Event	13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009 - Jeju, Korea, Republic of Duration: 1 Nov 2009 → 5 Nov 2009 Conference number: 13

Conference

Conference	13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009
Abbreviated title	MicroTAS
Country/Territory	Korea, Republic of
City	Jeju
Period	1/11/09 → 5/11/09

Keywords

Microwell array
Self-assembly
Tissue engineering
Vasculogenesis

Cite this

Rivron, N. C., Le Gac, S., Vrij, E., Rouwkema, J., Wijnperlé, D., Truckenmuller, R., Van Den Berg, A., & Van Blitterswijk, C. A. (2009). Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 9-11). The Chemical and Biological Microsystems Society.

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title = "Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach",

abstract = "Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.",

keywords = "Microwell array, Self-assembly, Tissue engineering, Vasculogenesis",

author = "Rivron, {N. C.} and {Le Gac}, S. and E. Vrij and J. Rouwkema and D. Wijnperl{\'e} and R. Truckenmuller and {Van Den Berg}, A. and {Van Blitterswijk}, {C. A.}",

year = "2009",

month = jan,

day = "1",

language = "English",

isbn = "9780979806421",

pages = "9--11",

booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "The Chemical and Biological Microsystems Society",

note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009, MicroTAS ; Conference date: 01-11-2009 Through 05-11-2009",

}

Rivron, NC, Le Gac, S, Vrij, E, Rouwkema, J , Wijnperlé, D, Truckenmuller, R, Van Den Berg, A & Van Blitterswijk, CA 2009, Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach. in Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, pp. 9-11, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009, Jeju, Korea, Republic of, 1/11/09.

Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach. / Rivron, N. C.; Le Gac, S.; Vrij, E. et al.
Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, 2009. p. 9-11.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach

AU - Rivron, N. C.

AU - Le Gac, S.

AU - Vrij, E.

AU - Rouwkema, J.

AU - Wijnperlé, D.

AU - Truckenmuller, R.

AU - Van Den Berg, A.

AU - Van Blitterswijk, C. A.

N1 - Conference code: 13

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

AB - Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

KW - Microwell array

KW - Self-assembly

KW - Tissue engineering

KW - Vasculogenesis

UR - http://www.scopus.com/inward/record.url?scp=84898618801&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84898618801

SN - 9780979806421

SP - 9

EP - 11

BT - Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - The Chemical and Biological Microsystems Society

T2 - 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009

Y2 - 1 November 2009 through 5 November 2009

ER -

Rivron NC, Le Gac S, Vrij E, Rouwkema J , Wijnperlé D, Truckenmuller R et al. Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society. 2009. p. 9-11

Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach

Abstract

Conference

Keywords

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Cite this