Microfabrication of shaped MM-scale tissues to study vascular development using a modular bottom-up approach

N. C. Rivron, S. Le Gac, E. Vrij, J. Rouwkema, D. Wijnperlé, R. Truckenmuller, A. Van Den Berg, C. A. Van Blitterswijk

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    1 Citation (Scopus)

    Abstract

    Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

    Original languageEnglish
    Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    PublisherThe Chemical and Biological Microsystems Society
    Pages9-11
    Number of pages3
    ISBN (Print)9780979806421
    Publication statusPublished - 1 Jan 2009
    Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009 - Jeju, Korea, Republic of
    Duration: 1 Nov 20095 Nov 2009
    Conference number: 13

    Conference

    Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2009
    Abbreviated titleMicroTAS
    CountryKorea, Republic of
    CityJeju
    Period1/11/095/11/09

    Keywords

    • Microwell array
    • Self-assembly
    • Tissue engineering
    • Vasculogenesis

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