Microfluidic apoptosis chip for drug screening to improve and personalize cancer therapy

F. Wolbers, H.R. Franke, Helene Andersson, I. Vermes, I. Vermes, Albert van den Berg

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    Currently, the knowledge on breast cancer treatment is increasing, however, there are still hardly any assays present to match patients to the right form of therapy to enhance the therapeutic effectiveness. Therefore a microfluidic device is developed to analyze the hormonal and chemosensitivity of first breast cancer cell lines (MCF-7) and in a later stage a patients’ own tumor cells. The apoptotic inducers tumor ne-crosis factor-α, in combination with cycloheximide, and staurosporine stained MCF-7 cells positive for Annexin V and PI, and showed a decrease in area coverage as compared to untreated cells.
    Original languageUndefined
    Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    EditorsL.E. Locascio, M. Gaitan, B.M. Paegel, D.J. Ross, W.N. Vreeland
    Place of PublicationSan Diego
    PublisherChemical and Biological Micro Systems Society
    Pages549-551
    Number of pages3
    ISBN (Print)978-0-9798064-1-4
    Publication statusPublished - 12 Oct 2008
    Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2008 - San Diego, United States
    Duration: 12 Oct 200816 Oct 2008
    Conference number: 12

    Publication series

    NameMicro Total Analysis Systems
    PublisherChemical and Biological Micro Systems Society
    Volume1
    ISSN (Print)1556-5890

    Conference

    Conference12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2008
    Abbreviated titleMicroTAS
    CountryUnited States
    CitySan Diego
    Period12/10/0816/10/08

    Keywords

    • EWI-14978
    • METIS-256143
    • IR-62715

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