Microfluidic-based detection platform for on-the-flow analyte characterization

Peter Kiesel; Markus Beck; Noble Johnson; Michael Bassler

doi:10.1117/12.840564

Microfluidic-based detection platform for on-the-flow analyte characterization

Peter Kiesel, Markus Beck, Noble Johnson, Michael Bassler

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Abstract

While commercial flow cytometers are sophisticated analytical instruments extensively used in research and clinical laboratories, they do not meet the challenging practical requirements for point-of-care (POC) diagnostics. In this paper we will describe and illustrate a new detection technique that will enable a compact, microfluidic-based flow cytometer that satisfies POC specifications for performance, robustness, compactness, cost, reagent consumption, and ease of use. The technology has been demonstrated with CD4 counts in whole blood.

Original language	English
Article number	760608
Journal	Proceedings of SPIE - the international society for optical engineering
Volume	7606
DOIs	https://doi.org/10.1117/12.840564
Publication status	Published - 2010
Externally published	Yes

Keywords

flow cytometer
opto-fluidics
on-the-flow analyte characterization
micro-fluidics

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abstract = "While commercial flow cytometers are sophisticated analytical instruments extensively used in research and clinical laboratories, they do not meet the challenging practical requirements for point-of-care (POC) diagnostics. In this paper we will describe and illustrate a new detection technique that will enable a compact, microfluidic-based flow cytometer that satisfies POC specifications for performance, robustness, compactness, cost, reagent consumption, and ease of use. The technology has been demonstrated with CD4 counts in whole blood.",

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AU - Johnson, Noble

AU - Bassler, Michael

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AB - While commercial flow cytometers are sophisticated analytical instruments extensively used in research and clinical laboratories, they do not meet the challenging practical requirements for point-of-care (POC) diagnostics. In this paper we will describe and illustrate a new detection technique that will enable a compact, microfluidic-based flow cytometer that satisfies POC specifications for performance, robustness, compactness, cost, reagent consumption, and ease of use. The technology has been demonstrated with CD4 counts in whole blood.

KW - flow cytometer

KW - opto-fluidics

KW - on-the-flow analyte characterization

KW - micro-fluidics

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DO - 10.1117/12.840564

M3 - Article

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JO - Proceedings of SPIE - the international society for optical engineering

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Microfluidic-based detection platform for on-the-flow analyte characterization

Abstract

Keywords

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