Microfluidic fabrication of responsive hierarchical microscale particles from macroscale materials and nanoscale particles

Juan Wang, Jan C.T. Eijkel, Mingliang Jin, Shuting Xie, Dong Yuan, Guofu Zhou, Albert van den Berg, Lingling Shui*

*Corresponding author for this work

    Research output: Contribution to journalReview articleAcademicpeer-review

    20 Citations (Scopus)


    Stimuli-responsive microparticles have been widely applied in sensors, actuators, chemical and biomedical analysis, and optoelectronic devices. Microfluidic technology has been demonstrated as a powerful top-down tool to create hierarchical microparticles with exquisite control over size, uniformity, morphology, structure and chemical composition. With the exploration of materials, various stimuli-responsive materials have been obtained, responding to magnetic, thermal, electrical, light and chemical stimuli. Self-assembly of nanoparticles is a quick bottom-up approach for the generation of functional materials with collective optical, electrical and magnetic properties. By combining macroscale materials and nanoscale particles using microfluidic technology, smart microparticles can be fabricated, possessing the responsive properties from the composing materials, the high surface-to-volume ratio and enhanced field effect from self-assembled nanostructures, and the advantages from microfluidics for controlling composition and structure of monodisperse microparticles. Therefore, better controlled physical and chemical properties and more sensitive and efficient performance can be achieved. In this review, we summarize the current status of the stimuli-responsive microparticles fabricated by microfluidic technology using polymers and nanoparticles, focusing on the microfluidic platforms, selection of responsive materials, and the achieved functions and applications.

    Original languageEnglish
    Pages (from-to)78-91
    Number of pages14
    JournalSensors and actuators. B: Chemical
    Publication statusPublished - 2017


    • Hierarchical microparticle
    • Microfluidics
    • Nanoparticle
    • Self-assembly
    • Stimuli-responsive


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