Abstract
Statement of Purpose: Colorectal cancer is the third most common cancer and its incidence increases with ageing. Understanding the mechanisms of tumour growth rely in further advances to unveil cancer-causing agents, drug screening and in the development of personalized therapies. Standard 2D in vitro models and in vivo animal models have undoubtedly contributed to the development of anti-cancer drug candidates. Yet their translation into successful clinical trials is critically low, which reinforces the need of a deeper understanding of tumorigenesis (1). Therefore, 3D models integrating tissue engineering (TE) strategies with microfluidic technology have sparked the expectation on physiologically relevant microfluidic in vitro models (2). The aim of this work is to establish a 3D microfluidic model that enables the reconstitution of physiological functions of microvascular tissue that emulates the human colorectal tumor microenvironment. This model will be established via a microfluidic device with an encapsulating hydrogel compartment comprising a co-culture system of HCT-116 colorectal cancer cells and human intestinal microvascular endothelial cells.
Original language | English |
---|---|
Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 |
Subtitle of host publication | The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
Publisher | Society for Biomaterials |
Pages | 413 |
Number of pages | 1 |
ISBN (Electronic) | 9781510883901 |
Publication status | Published - 2019 |
Externally published | Yes |
Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: 3 Apr 2019 → 6 Apr 2019 Conference number: 42 https://2019.biomaterials.org/ |
Publication series
Name | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
---|---|
Volume | 40 |
ISSN (Print) | 1526-7547 |
Conference
Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019 |
---|---|
Country/Territory | United States |
City | Seattle |
Period | 3/04/19 → 6/04/19 |
Internet address |