Microfluidic gradient generator for drug testing on a colorectal tumor-on-a-chip disease model

Mariana Carvalho, David Barata, Liliana Teixeira, Stefan Giselbrecht, Rui Reis, Joaquim Oliveira, Pamela Habibović, Roman Truckenmüller

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Statement of Purpose: Colorectal cancer is the third most common cancer and its incidence increases with ageing. Understanding the mechanisms of tumour growth rely in further advances to unveil cancer-causing agents, drug screening and in the development of personalized therapies. Standard 2D in vitro models and in vivo animal models have undoubtedly contributed to the development of anti-cancer drug candidates. Yet their translation into successful clinical trials is critically low, which reinforces the need of a deeper understanding of tumorigenesis (1). Therefore, 3D models integrating tissue engineering (TE) strategies with microfluidic technology have sparked the expectation on physiologically relevant microfluidic in vitro models (2). The aim of this work is to establish a 3D microfluidic model that enables the reconstitution of physiological functions of microvascular tissue that emulates the human colorectal tumor microenvironment. This model will be established via a microfluidic device with an encapsulating hydrogel compartment comprising a co-culture system of HCT-116 colorectal cancer cells and human intestinal microvascular endothelial cells.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages413
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 3 Apr 20196 Apr 2019
Conference number: 42
https://2019.biomaterials.org/

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019
CountryUnited States
CitySeattle
Period3/04/196/04/19
Internet address

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