59 Citations (Scopus)
35 Downloads (Pure)

Abstract

Vascular cell biology is an area of research with great biomedical relevance. Vascular dysfunction is involved in major diseases such as atherosclerosis, diabetes, and cancer. However, when studying vascular cell biology in the laboratory, it is difficult to mimic the dynamic, three-dimensional microenvironment that is found in vivo. Microfluidic technology offers unique possibilities to overcome this difficulty. In this review, an overview of the recent applications of microfluidic technology in the field of vascular biological research will be given. Examples of how microfluidics can be used to generate shear stresses, growth factor gradients, cocultures, and migration assays will be provided. The use of microfluidic devices in studying three-dimensional models of vascular tissue will be discussed. It is concluded that microfluidic technology offers great possibilities to systematically study vascular cell biology with setups that more closely mimic the in vivo situation than those that are generated with conventional methods.
Original languageUndefined
Pages (from-to)-
Number of pages10
JournalJournal of biomedicine and biotechnology
VolumeID
Issue number823148
DOIs
Publication statusPublished - 2009

Keywords

  • METIS-262470
  • IR-69511

Cite this

@article{f63c47fd70374167af1c0886172762c3,
title = "Microfluidic technology in vascular research",
abstract = "Vascular cell biology is an area of research with great biomedical relevance. Vascular dysfunction is involved in major diseases such as atherosclerosis, diabetes, and cancer. However, when studying vascular cell biology in the laboratory, it is difficult to mimic the dynamic, three-dimensional microenvironment that is found in vivo. Microfluidic technology offers unique possibilities to overcome this difficulty. In this review, an overview of the recent applications of microfluidic technology in the field of vascular biological research will be given. Examples of how microfluidics can be used to generate shear stresses, growth factor gradients, cocultures, and migration assays will be provided. The use of microfluidic devices in studying three-dimensional models of vascular tissue will be discussed. It is concluded that microfluidic technology offers great possibilities to systematically study vascular cell biology with setups that more closely mimic the in vivo situation than those that are generated with conventional methods.",
keywords = "METIS-262470, IR-69511",
author = "{van der Meer}, {Andries Dirk} and Poot, {Andreas A.} and Duits, {Michael H.G.} and Jan Feijen and I. Vermes",
note = "Open access article",
year = "2009",
doi = "10.1155/2009/823148",
language = "Undefined",
volume = "ID",
pages = "--",
journal = "Journal of biomedicine and biotechnology",
issn = "1110-7243",
publisher = "Hindawi Publishing Corporation",
number = "823148",

}

Microfluidic technology in vascular research. / van der Meer, Andries Dirk; Poot, Andreas A.; Duits, Michael H.G.; Feijen, Jan; Vermes, I.

In: Journal of biomedicine and biotechnology, Vol. ID, No. 823148, 2009, p. -.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Microfluidic technology in vascular research

AU - van der Meer, Andries Dirk

AU - Poot, Andreas A.

AU - Duits, Michael H.G.

AU - Feijen, Jan

AU - Vermes, I.

N1 - Open access article

PY - 2009

Y1 - 2009

N2 - Vascular cell biology is an area of research with great biomedical relevance. Vascular dysfunction is involved in major diseases such as atherosclerosis, diabetes, and cancer. However, when studying vascular cell biology in the laboratory, it is difficult to mimic the dynamic, three-dimensional microenvironment that is found in vivo. Microfluidic technology offers unique possibilities to overcome this difficulty. In this review, an overview of the recent applications of microfluidic technology in the field of vascular biological research will be given. Examples of how microfluidics can be used to generate shear stresses, growth factor gradients, cocultures, and migration assays will be provided. The use of microfluidic devices in studying three-dimensional models of vascular tissue will be discussed. It is concluded that microfluidic technology offers great possibilities to systematically study vascular cell biology with setups that more closely mimic the in vivo situation than those that are generated with conventional methods.

AB - Vascular cell biology is an area of research with great biomedical relevance. Vascular dysfunction is involved in major diseases such as atherosclerosis, diabetes, and cancer. However, when studying vascular cell biology in the laboratory, it is difficult to mimic the dynamic, three-dimensional microenvironment that is found in vivo. Microfluidic technology offers unique possibilities to overcome this difficulty. In this review, an overview of the recent applications of microfluidic technology in the field of vascular biological research will be given. Examples of how microfluidics can be used to generate shear stresses, growth factor gradients, cocultures, and migration assays will be provided. The use of microfluidic devices in studying three-dimensional models of vascular tissue will be discussed. It is concluded that microfluidic technology offers great possibilities to systematically study vascular cell biology with setups that more closely mimic the in vivo situation than those that are generated with conventional methods.

KW - METIS-262470

KW - IR-69511

U2 - 10.1155/2009/823148

DO - 10.1155/2009/823148

M3 - Article

VL - ID

SP - -

JO - Journal of biomedicine and biotechnology

JF - Journal of biomedicine and biotechnology

SN - 1110-7243

IS - 823148

ER -