Microfluidic technology in vascular research: the endothelial response to shear stress

Research output: ThesisPhD Thesis - Research UT, graduation UT

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Abstract

Vascular endothelial cells form the inner lining of all blood vessels. These cells are highly responsive to the shear stress that is caused by blood flowing over their surface. In this thesis, several aspects of the endothelial response to shear stress are studied. The experiments focus on signal transduction, cytoskeletal remodeling, migration, micromechanical changes and uptake of low density lipoprotein. Most of these experiments were performed by using microfluidic set-ups. In these set-ups, cells are cultured and subjected to experimental conditions in micrometer-sized channels. Several advantages and challenges associated with applying this new technology in vascular research are discussed.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Vermes, I., Supervisor
  • Feijen, J., Supervisor
  • Poot, A.A., Co-Supervisor
Award date10 Mar 2010
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-2978-5
DOIs
Publication statusPublished - 10 Mar 2010

Fingerprint

Microfluidics
Blood Vessels
Technology
LDL Lipoproteins
Research
Cultured Cells
Signal Transduction
Endothelial Cells

Keywords

  • METIS-269985

Cite this

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abstract = "Vascular endothelial cells form the inner lining of all blood vessels. These cells are highly responsive to the shear stress that is caused by blood flowing over their surface. In this thesis, several aspects of the endothelial response to shear stress are studied. The experiments focus on signal transduction, cytoskeletal remodeling, migration, micromechanical changes and uptake of low density lipoprotein. Most of these experiments were performed by using microfluidic set-ups. In these set-ups, cells are cultured and subjected to experimental conditions in micrometer-sized channels. Several advantages and challenges associated with applying this new technology in vascular research are discussed.",
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Microfluidic technology in vascular research: the endothelial response to shear stress. / van der Meer, Andries Dirk.

Enschede : Universiteit Twente, 2010. 107 p.

Research output: ThesisPhD Thesis - Research UT, graduation UT

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N2 - Vascular endothelial cells form the inner lining of all blood vessels. These cells are highly responsive to the shear stress that is caused by blood flowing over their surface. In this thesis, several aspects of the endothelial response to shear stress are studied. The experiments focus on signal transduction, cytoskeletal remodeling, migration, micromechanical changes and uptake of low density lipoprotein. Most of these experiments were performed by using microfluidic set-ups. In these set-ups, cells are cultured and subjected to experimental conditions in micrometer-sized channels. Several advantages and challenges associated with applying this new technology in vascular research are discussed.

AB - Vascular endothelial cells form the inner lining of all blood vessels. These cells are highly responsive to the shear stress that is caused by blood flowing over their surface. In this thesis, several aspects of the endothelial response to shear stress are studied. The experiments focus on signal transduction, cytoskeletal remodeling, migration, micromechanical changes and uptake of low density lipoprotein. Most of these experiments were performed by using microfluidic set-ups. In these set-ups, cells are cultured and subjected to experimental conditions in micrometer-sized channels. Several advantages and challenges associated with applying this new technology in vascular research are discussed.

KW - METIS-269985

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