Microfluidic valves with integrated structured elastomeric membranes for reversible fluidic entrapment and in situ channel functionalization

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

We report the utility Of Structured elastomeric membranes (SEMs) its it multifunctional microfluidic These Structured membranes are part of a two-layer microfluidic device. analogous to membrane tool. valves, with the novelty that they incorporate topographical features oil the roof of the fluid channel. We demonstrate that when the topographical features are recessed into the roof of the fluid channel, actuation of the membrane leads to effective confinement of fluids down to femtolitres in Preformed microfluidic containers. Thus, the SEMs in this case function its fluidic traps that Could be Coupled to microfluidic networks for rapid and repeated flushing of solvents. Alternatively. when the topographical features oil the roof protrude into the fluid channel, we demonstrate that the SEMs call be used to pattern proteins and cells in microchannels. Thus ill this case, the SEMs serve its fluidic stamps for functionalizing microchannel surfaces. In addition. we show that the trap or pattern shape and size call be manipulated simply by varying the topography oil the elastomeric membrane. Since SEW membrane valves and Pumps use similar fabrication technology, we believe that SEMs call be integrated into microfluidic large-scale circuits for biotechnological applications.
Original languageUndefined
Article number10.1039/b818712f
Pages (from-to)1461-1467
Number of pages7
JournalLab on a chip
Volume9
Issue number10
DOIs
Publication statusPublished - 21 May 2009

Keywords

  • METIS-264116
  • IR-68302
  • Cells
  • EWI-16443
  • Large-scale integration
  • Surfaces
  • Soft Lithography
  • Networks

Cite this

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title = "Microfluidic valves with integrated structured elastomeric membranes for reversible fluidic entrapment and in situ channel functionalization",
abstract = "We report the utility Of Structured elastomeric membranes (SEMs) its it multifunctional microfluidic These Structured membranes are part of a two-layer microfluidic device. analogous to membrane tool. valves, with the novelty that they incorporate topographical features oil the roof of the fluid channel. We demonstrate that when the topographical features are recessed into the roof of the fluid channel, actuation of the membrane leads to effective confinement of fluids down to femtolitres in Preformed microfluidic containers. Thus, the SEMs in this case function its fluidic traps that Could be Coupled to microfluidic networks for rapid and repeated flushing of solvents. Alternatively. when the topographical features oil the roof protrude into the fluid channel, we demonstrate that the SEMs call be used to pattern proteins and cells in microchannels. Thus ill this case, the SEMs serve its fluidic stamps for functionalizing microchannel surfaces. In addition. we show that the trap or pattern shape and size call be manipulated simply by varying the topography oil the elastomeric membrane. Since SEW membrane valves and Pumps use similar fabrication technology, we believe that SEMs call be integrated into microfluidic large-scale circuits for biotechnological applications.",
keywords = "METIS-264116, IR-68302, Cells, EWI-16443, Large-scale integration, Surfaces, Soft Lithography, Networks",
author = "Srinivas Vanapalli and {Vanapalli Veera}, V.S.A.R. and Dani{\"e}l Wijnperle and {van den Berg}, Albert and Mugele, {Friedrich Gunther} and Duits, {Michael H.G.}",
note = "10.1039/b818712f",
year = "2009",
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day = "21",
doi = "10.1039/b818712f",
language = "Undefined",
volume = "9",
pages = "1461--1467",
journal = "Lab on a chip",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
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Microfluidic valves with integrated structured elastomeric membranes for reversible fluidic entrapment and in situ channel functionalization. / Vanapalli, Srinivas; Vanapalli Veera, V.S.A.R.; Wijnperle, Daniël; van den Berg, Albert; Mugele, Friedrich Gunther; Duits, Michael H.G.

In: Lab on a chip, Vol. 9, No. 10, 10.1039/b818712f, 21.05.2009, p. 1461-1467.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Microfluidic valves with integrated structured elastomeric membranes for reversible fluidic entrapment and in situ channel functionalization

AU - Vanapalli, Srinivas

AU - Vanapalli Veera, V.S.A.R.

AU - Wijnperle, Daniël

AU - van den Berg, Albert

AU - Mugele, Friedrich Gunther

AU - Duits, Michael H.G.

N1 - 10.1039/b818712f

PY - 2009/5/21

Y1 - 2009/5/21

N2 - We report the utility Of Structured elastomeric membranes (SEMs) its it multifunctional microfluidic These Structured membranes are part of a two-layer microfluidic device. analogous to membrane tool. valves, with the novelty that they incorporate topographical features oil the roof of the fluid channel. We demonstrate that when the topographical features are recessed into the roof of the fluid channel, actuation of the membrane leads to effective confinement of fluids down to femtolitres in Preformed microfluidic containers. Thus, the SEMs in this case function its fluidic traps that Could be Coupled to microfluidic networks for rapid and repeated flushing of solvents. Alternatively. when the topographical features oil the roof protrude into the fluid channel, we demonstrate that the SEMs call be used to pattern proteins and cells in microchannels. Thus ill this case, the SEMs serve its fluidic stamps for functionalizing microchannel surfaces. In addition. we show that the trap or pattern shape and size call be manipulated simply by varying the topography oil the elastomeric membrane. Since SEW membrane valves and Pumps use similar fabrication technology, we believe that SEMs call be integrated into microfluidic large-scale circuits for biotechnological applications.

AB - We report the utility Of Structured elastomeric membranes (SEMs) its it multifunctional microfluidic These Structured membranes are part of a two-layer microfluidic device. analogous to membrane tool. valves, with the novelty that they incorporate topographical features oil the roof of the fluid channel. We demonstrate that when the topographical features are recessed into the roof of the fluid channel, actuation of the membrane leads to effective confinement of fluids down to femtolitres in Preformed microfluidic containers. Thus, the SEMs in this case function its fluidic traps that Could be Coupled to microfluidic networks for rapid and repeated flushing of solvents. Alternatively. when the topographical features oil the roof protrude into the fluid channel, we demonstrate that the SEMs call be used to pattern proteins and cells in microchannels. Thus ill this case, the SEMs serve its fluidic stamps for functionalizing microchannel surfaces. In addition. we show that the trap or pattern shape and size call be manipulated simply by varying the topography oil the elastomeric membrane. Since SEW membrane valves and Pumps use similar fabrication technology, we believe that SEMs call be integrated into microfluidic large-scale circuits for biotechnological applications.

KW - METIS-264116

KW - IR-68302

KW - Cells

KW - EWI-16443

KW - Large-scale integration

KW - Surfaces

KW - Soft Lithography

KW - Networks

U2 - 10.1039/b818712f

DO - 10.1039/b818712f

M3 - Article

VL - 9

SP - 1461

EP - 1467

JO - Lab on a chip

JF - Lab on a chip

SN - 1473-0197

IS - 10

M1 - 10.1039/b818712f

ER -