Micromolding of solvent resistant microfluidic devices,

Theodorus J.A. Renckens, Dainius Janeliunas, Hilbert van Vliet, Jan H. van Esch, Guido Mul, Michiel T. Kreutzer

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
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We demonstrate a rapid fabrication procedure for solvent-resistant microfluidic devices based on the perfluoropolyether (PFPE) SIFEL. We carefully modified the poly-dimethylsiloxane (PDMS) micromolding procedure, such that it can still be executed using the standard facilities for PDMS devices. Most importantly, devices with a thin SIFEL layer for the patterned channels and a PDMS support layer on top offered the best of two worlds in terms of chemical and mechanical stability during fabrication and use. Tests revealed that these devices overcome two important drawbacks of PDMS devices: (i) incompatibility with almost all non-aqueous solvents, and (ii) leaching of oligomer into solution. The potential of our device is shown by performing a relevant organic synthesis reaction with aggressive reactants and solvents. PFPE-PDMS devices will greatly expand the application window of micromolded devices
Original languageEnglish
Pages (from-to)2035-2038
Number of pages4
JournalLab on a chip
Issue number12
Publication statusPublished - 2011


  • IR-95301
  • METIS-280311


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