Microporous calcium phosphate ceramics driving osteogenesis through surface architecture

Jingwei Zhang*, Davide Barbieri*, Hetty ten Hoopen, Joost D. de Bruijn, Clemens A. van Blitterswijk, Huipin Yuan

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)
27 Downloads (Pure)

Abstract

The presence of micropores in calcium phosphate (CaP) ceramics has shown its important role in initiating inductive bone formation in ectopic sites. To investigate how microporous CaP ceramics trigger osteoinduction, we optimized two biphasic CaP ceramics (i.e., BCP-R and BCP-S) to have the same chemical composition, equivalent surface area per volume, comparable protein adsorption, similar ion (i.e., calcium and phosphate) exchange and the same surface mineralization potential, but different surface architecture. In particular, BCP-R had a surface roughness (Ra) of 325.4 ± 58.9 nm while for BCP-S it was 231.6 ± 35.7 nm. Ceramic blocks with crossing or noncrossing channels of 250, 500, 1000, and 2000 µm were implanted in paraspinal muscle of dogs for 12 weeks. The percentage of bone volume in the channels was not affected by the type of pores (i.e., crossing vs. closed) or their size, but it was greatly influenced by the ceramic type (i.e., BCP-R vs. BCP-S). Significantly, more bone was formed in the channels of BCP-R than in those of BCP-S. Since the two CaP ceramics differed only in their surface architecture, the results hereby demonstrate that microporous CaP ceramics may induce ectopic osteogenesis through surface architecture.
Original languageEnglish
Pages (from-to)1188-1199
Number of pages12
JournalJournal of biomedical materials research. Part A
Volume103
Issue number3
Early online date28 Jan 2015
DOIs
Publication statusPublished - Mar 2015

Keywords

  • bone grafting
  • calcium phosphate ceramics
  • microstructure
  • surface architecture
  • osteogenesis
  • 2023 OA procedure

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