Microstructure analysis of biocompatible phosphoester copolymers

Tobias Steinbach; Romina Schröder; Sandra Ritz; Frederik R. Wurm

doi:10.1039/c3py00563a

Microstructure analysis of biocompatible phosphoester copolymers

Tobias Steinbach, Romina Schröder, Sandra Ritz, Frederik R. Wurm^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

47 Citations (Scopus)

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Abstract

Copolymers with varying compositions of 2-ethoxy-2-oxo-1,3,2- dioxaphospholane (EEP) and 2-ethoxy-4-methyl-2-oxo-1,3,2-dioxaphospholane (EMEP) have been synthesized via 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed anionic ring-opening polymerization. The molecular weights and comonomer ratios were well controlled and polymers with reasonable molecular weight distributions (<1.5) were obtained in all cases. The copolymers were investigated by ¹H and ³¹P NMR spectroscopies to determine the underlying microstructure via detailed dyad analysis. The copolymers were found to be nontoxic to HeLa cells. Furthermore, the obtained copolymers of EEP and EMEP show thermoresponsive properties, i.e., exhibit a lower critical solution temperature (LCST).

Original language	English
Pages (from-to)	4469-4479
Number of pages	11
Journal	Polymer chemistry
Volume	4
Issue number	16
DOIs	https://doi.org/10.1039/c3py00563a
Publication status	Published - 21 Aug 2013
Externally published	Yes

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title = "Microstructure analysis of biocompatible phosphoester copolymers",

abstract = "Copolymers with varying compositions of 2-ethoxy-2-oxo-1,3,2- dioxaphospholane (EEP) and 2-ethoxy-4-methyl-2-oxo-1,3,2-dioxaphospholane (EMEP) have been synthesized via 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed anionic ring-opening polymerization. The molecular weights and comonomer ratios were well controlled and polymers with reasonable molecular weight distributions (<1.5) were obtained in all cases. The copolymers were investigated by 1H and 31P NMR spectroscopies to determine the underlying microstructure via detailed dyad analysis. The copolymers were found to be nontoxic to HeLa cells. Furthermore, the obtained copolymers of EEP and EMEP show thermoresponsive properties, i.e., exhibit a lower critical solution temperature (LCST).",

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T1 - Microstructure analysis of biocompatible phosphoester copolymers

AU - Steinbach, Tobias

AU - Schröder, Romina

AU - Ritz, Sandra

AU - Wurm, Frederik R.

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Y1 - 2013/8/21

N2 - Copolymers with varying compositions of 2-ethoxy-2-oxo-1,3,2- dioxaphospholane (EEP) and 2-ethoxy-4-methyl-2-oxo-1,3,2-dioxaphospholane (EMEP) have been synthesized via 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed anionic ring-opening polymerization. The molecular weights and comonomer ratios were well controlled and polymers with reasonable molecular weight distributions (<1.5) were obtained in all cases. The copolymers were investigated by 1H and 31P NMR spectroscopies to determine the underlying microstructure via detailed dyad analysis. The copolymers were found to be nontoxic to HeLa cells. Furthermore, the obtained copolymers of EEP and EMEP show thermoresponsive properties, i.e., exhibit a lower critical solution temperature (LCST).

AB - Copolymers with varying compositions of 2-ethoxy-2-oxo-1,3,2- dioxaphospholane (EEP) and 2-ethoxy-4-methyl-2-oxo-1,3,2-dioxaphospholane (EMEP) have been synthesized via 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed anionic ring-opening polymerization. The molecular weights and comonomer ratios were well controlled and polymers with reasonable molecular weight distributions (<1.5) were obtained in all cases. The copolymers were investigated by 1H and 31P NMR spectroscopies to determine the underlying microstructure via detailed dyad analysis. The copolymers were found to be nontoxic to HeLa cells. Furthermore, the obtained copolymers of EEP and EMEP show thermoresponsive properties, i.e., exhibit a lower critical solution temperature (LCST).

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Microstructure analysis of biocompatible phosphoester copolymers

Abstract

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