Microwave‐heated γ‐Alumina Applied to the Reduction of Aldehydes to Alcohols

Bhausaheb Dhokale, Arturo Susarrey Arce*, Anna Pekkari, August Runemark, Kasper Moth-Poulsen, Christoph Langhammer, Hanna Härelind, Michael Busch, Matthias Vandichel*, Henrik Sundén*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The development of cheap and robust heterogeneous catalysts for the Meerwein‐Ponndorf‐Verley (MPV) reduction is desirable due to the difficulties in product isolation and catalyst recovery associated with the traditional use of homogeneous catalysts for MPV. Herein, we show that microwave heated γ‐Al2O3 can be used for the reduction of aldehydes to alcohols. The reaction is efficient and has a broad substrates scope (19 entries). The products can be isolated by simple filtration, and the catalyst can be regenerated. With the use of microwave heating, we can direct the heating to the catalyst rather than to the whole reaction medium. Furthermore, DFT was used to study the reaction mechanism, and we can conclude that a dual‐site mechanism is operative where the aldehyde and 2‐propoxide are situated on two adjacent Al sites during the reduction. Additionally, volcano plots were used to rationalize the reactivity of Al2O3 in comparison to other metal oxides.
Original languageEnglish
Pages (from-to)6344-6355
Number of pages12
JournalChemCatChem
Volume12
Issue number24
Early online date23 Oct 2020
DOIs
Publication statusPublished - 16 Dec 2020

Keywords

  • MPV reduction
  • Microwave-assisted catalysis
  • γ-Al O
  • gamma-Al2O3

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