Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution

Floris Teunis Gerardus van den Brink, Ashish Asthana, Johan G. Bomer, E.A. Tolner, A.M.J.M. van den Maagdenberg, Mathieu Odijk

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    Abstract

    We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.
    Original languageEnglish
    Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
    EditorsAbraham Lee, Don DeVoe
    Place of PublicationSavannah
    PublisherChemical and Biological Microstystems Society
    Pages215-216
    Number of pages2
    ISBN (Electronic)978-0-692-94183-6
    Publication statusPublished - 26 Oct 2017
    Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States
    Duration: 22 Oct 201726 Oct 2017
    Conference number: 21
    https://www.microtas2017.org/

    Conference

    Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017
    Abbreviated titleMicroTAS
    CountryUnited States
    CitySavannah
    Period22/10/1726/10/17
    Internet address

    Fingerprint

    Sampling
    Acetylcholine
    Neurotransmitter Agents
    Glutamic Acid
    Data storage equipment
    Monitoring

    Keywords

    • Microdialysis
    • Push-pull perfusion sampling
    • droplets
    • Neuroprobe

    Cite this

    van den Brink, F. T. G., Asthana, A., Bomer, J. G., Tolner, E. A., van den Maagdenberg, A. M. J. M., & Odijk, M. (2017). Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 215-216). Savannah: Chemical and Biological Microstystems Society.
    van den Brink, Floris Teunis Gerardus ; Asthana, Ashish ; Bomer, Johan G. ; Tolner, E.A. ; van den Maagdenberg, A.M.J.M. ; Odijk, Mathieu . / Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / Abraham Lee ; Don DeVoe. Savannah : Chemical and Biological Microstystems Society, 2017. pp. 215-216
    @inproceedings{6bf61dffb2984a70bc975c1cea712ea0,
    title = "Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution",
    abstract = "We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.",
    keywords = "Microdialysis, Push-pull perfusion sampling, droplets, Neuroprobe",
    author = "{van den Brink}, {Floris Teunis Gerardus} and Ashish Asthana and Bomer, {Johan G.} and E.A. Tolner and {van den Maagdenberg}, A.M.J.M. and Mathieu Odijk",
    year = "2017",
    month = "10",
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    van den Brink, FTG, Asthana, A, Bomer, JG, Tolner, EA, van den Maagdenberg, AMJM & Odijk, M 2017, Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. in A Lee & D DeVoe (eds), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microstystems Society, Savannah, pp. 215-216, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017, Savannah, United States, 22/10/17.

    Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. / van den Brink, Floris Teunis Gerardus; Asthana, Ashish; Bomer, Johan G.; Tolner, E.A.; van den Maagdenberg, A.M.J.M.; Odijk, Mathieu .

    21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / Abraham Lee; Don DeVoe. Savannah : Chemical and Biological Microstystems Society, 2017. p. 215-216.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    AU - van den Brink, Floris Teunis Gerardus

    AU - Asthana, Ashish

    AU - Bomer, Johan G.

    AU - Tolner, E.A.

    AU - van den Maagdenberg, A.M.J.M.

    AU - Odijk, Mathieu

    PY - 2017/10/26

    Y1 - 2017/10/26

    N2 - We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.

    AB - We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.

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    KW - Push-pull perfusion sampling

    KW - droplets

    KW - Neuroprobe

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    BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences

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    van den Brink FTG, Asthana A, Bomer JG, Tolner EA, van den Maagdenberg AMJM, Odijk M. Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. In Lee A, DeVoe D, editors, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Savannah: Chemical and Biological Microstystems Society. 2017. p. 215-216