Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution

Floris Teunis Gerardus van den Brink, Ashish Asthana, Johan G. Bomer, E.A. Tolner, A.M.J.M. van den Maagdenberg, Mathieu Odijk

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.
Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsAbraham Lee, Don DeVoe
Place of PublicationSavannah
PublisherChemical and Biological Microstystems Society
Pages215-216
Number of pages2
ISBN (Electronic)978-0-692-94183-6
Publication statusPublished - 26 Oct 2017
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21
https://www.microtas2017.org/

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017
Abbreviated titleMicroTAS
CountryUnited States
CitySavannah
Period22/10/1726/10/17
Internet address

Fingerprint

Sampling
Acetylcholine
Neurotransmitter Agents
Glutamic Acid
Data storage equipment
Monitoring

Keywords

  • Microdialysis
  • Push-pull perfusion sampling
  • droplets
  • Neuroprobe

Cite this

van den Brink, F. T. G., Asthana, A., Bomer, J. G., Tolner, E. A., van den Maagdenberg, A. M. J. M., & Odijk, M. (2017). Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 215-216). Savannah: Chemical and Biological Microstystems Society.
van den Brink, Floris Teunis Gerardus ; Asthana, Ashish ; Bomer, Johan G. ; Tolner, E.A. ; van den Maagdenberg, A.M.J.M. ; Odijk, Mathieu . / Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / Abraham Lee ; Don DeVoe. Savannah : Chemical and Biological Microstystems Society, 2017. pp. 215-216
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abstract = "We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.",
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van den Brink, FTG, Asthana, A, Bomer, JG, Tolner, EA, van den Maagdenberg, AMJM & Odijk, M 2017, Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. in A Lee & D DeVoe (eds), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microstystems Society, Savannah, pp. 215-216, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017, Savannah, United States, 22/10/17.

Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. / van den Brink, Floris Teunis Gerardus; Asthana, Ashish; Bomer, Johan G.; Tolner, E.A.; van den Maagdenberg, A.M.J.M.; Odijk, Mathieu .

21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / Abraham Lee; Don DeVoe. Savannah : Chemical and Biological Microstystems Society, 2017. p. 215-216.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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AU - van den Brink, Floris Teunis Gerardus

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PY - 2017/10/26

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N2 - We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.

AB - We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.

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KW - Neuroprobe

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van den Brink FTG, Asthana A, Bomer JG, Tolner EA, van den Maagdenberg AMJM, Odijk M. Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. In Lee A, DeVoe D, editors, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Savannah: Chemical and Biological Microstystems Society. 2017. p. 215-216