Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution

Floris van den Brink, Ashish Asthana, Johan Bomer, Else Tolner, Arn van den Maagdenberg, Mathieu Odijk

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    Abstract

    We present a newly designed and fabricated miniaturized hybrid push-pull perfusion sampling (μPPPS) probe with integrated droplet generator to capture concentration variations of target analytes in ‘chemical memory’. The development of this tool will ultimately enable the monitoring of neurotransmitters with unprecedented temporal (~1 s) and spatial (<100 μm) precision, while requiring an absolute minimum of sample volume. The μPPPS probe is essential to gain deeper understanding of the fast dynamics in the release of neuromodulatory substances, such as acetylcholine or glutamate.
    Original languageEnglish
    Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
    EditorsAbraham Lee, Don DeVoe
    Place of PublicationSavannah
    PublisherChemical and Biological Microstystems Society
    Pages215-216
    Number of pages2
    ISBN (Electronic)978-0-692-94183-6
    Publication statusPublished - 26 Oct 2017
    Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States
    Duration: 22 Oct 201726 Oct 2017
    Conference number: 21
    https://www.microtas2017.org/

    Conference

    Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017
    Abbreviated titleMicroTAS
    CountryUnited States
    CitySavannah
    Period22/10/1726/10/17
    Internet address

    Keywords

    • Microdialysis
    • Push-pull perfusion sampling
    • Droplets
    • Neuroprobe

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  • Cite this

    van den Brink, F., Asthana, A., Bomer, J., Tolner, E., van den Maagdenberg, A., & Odijk, M. (2017). Miniaturized hybrid push-pull perfusion probe for sampling with high spatial and temporal resolution. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 215-216). Savannah: Chemical and Biological Microstystems Society.