Minimally invasive maxillofacial vertical bone augmentation using brushite based cements

Faleh Tamimi, Jesus Torres, Enrique Lopez-Cabarcos, David C. Bassett, Pamela Habibovic, Elena Luceron, Jake E. Barralet

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)


An ideal material for maxillofacial vertical bone augmentation procedures should not only be osteoconductive, biocompatible and mechanically strong, but should also be applied using minimally invasive procedures and remain stable with respect to the original bone surfaces. This way, implant exposure and infection might be reduced and good mechanical stability may be achieved. Calcium phosphate cements are proven biocompatible and osteoconductive materials that can be injected using minimally invasive procedures. Among these cements, brushite based cements have the added advantage of being biodegradable in vivo. Therefore, this material has the potential for use in the aforementioned procedures. An in vivo study was performed in rabbits to evaluate the potential use of brushite cements in minimally invasive maxillofacial vertical bone augmentation procedures. In this study, we injected self-setting brushite cements on the subperiosteal bone surface using a minimally invasive tunnelling technique. The cement pastes were stable on the bone surface and hardened soon after they were injected thereby negating the need for additional supports such as membranes or meshes. The animals were sacrificed 8 weeks after the intervention and histological observations revealed signs of successful vertical bone augmentation. Therefore, we have demonstrated a minimally invasive vertical bone augmentation procedure that is an attractive alternative to current surgical procedures in terms of increased simplicity, reduced trauma, and lower cost of surgery
Original languageUndefined
Pages (from-to)208-216
Issue number2
Publication statusPublished - 2009


  • Bone cement
  • Minimal invasive surgery
  • Injectable biomaterials
  • Biocompatibility
  • METIS-261078
  • IR-80978
  • Brushite
  • Vertical bone augmentation

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