Biotechnology and bio-manufacturing markets are continuously growing, generating new sources of many valuable healthcare and life science products including therapeutic proteins and polysaccharides, monoclonals, vaccines, diagnostics, pharmaceutical chemicals and enzymes. These bioproducts have to be isolated and purified from complex mixtures before they can be used to ensure safety and efficacy. Nowadays, there are different techniques available for biomolecules isolation and purification. Membrane filtration and chromatography methods are the most widely techniques used to obtain the required purity for biotherapeutics and diagnostic products. The advantages and disadvantages of these two methods are complementary to each others. Therefore, if these methods can be integrated into a one single unit operation, maximal yield can be combined with minimal product loss. Furthermore, the integration of different separation steps into one single unit operation increases the compactness, economics, and reduces the time to market.
|Award date||24 May 2007|
|Place of Publication||Enschede|
|Publication status||Published - 24 May 2007|