Mixed matrix membrane adsorbers for protein and blood purification


Research output: ThesisPhD Thesis - Research UT, graduation UT

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Biotechnology and bio-manufacturing markets are continuously growing, generating new sources of many valuable healthcare and life science products including therapeutic proteins and polysaccharides, monoclonals, vaccines, diagnostics, pharmaceutical chemicals and enzymes. These bioproducts have to be isolated and purified from complex mixtures before they can be used to ensure safety and efficacy. Nowadays, there are different techniques available for biomolecules isolation and purification. Membrane filtration and chromatography methods are the most widely techniques used to obtain the required purity for biotherapeutics and diagnostic products. The advantages and disadvantages of these two methods are complementary to each others. Therefore, if these methods can be integrated into a one single unit operation, maximal yield can be combined with minimal product loss. Furthermore, the integration of different separation steps into one single unit operation increases the compactness, economics, and reduces the time to market.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
  • Wessling, Matthias , Supervisor
  • Borneman, Zandrie , Co-Supervisor
Award date24 May 2007
Place of PublicationEnschede
Print ISBNs978-90-365-2507-7
Publication statusPublished - 24 May 2007


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