Mixed matrix membranes for process intensification in electrodialysis of amino acids

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9 Citations (Scopus)

Abstract

BACKGROUND Amino acids are valuable intermediates in the biobased economy for the production of chemicals. Electro-membrane processes combined with enzymatic modification have been investigated as an alternative technology for the fractionation of a mixture of amino acids with almost identical charge behavior. Up to now, the modification and subsequent separation were performed in two separate reactors. An interesting approach is the integration of both unit operations into one single device using mixed matrix membranes (MMMs) as platform for enzymatic conversion. RESULTS MMMs containing the enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) Relizyme EP403/S as carrier were prepared showing satisfactory mechanical stability and enzymatic activity for L-glutamic acid conversion into γ-aminobutyric acid (GABA). ED with integrated MMM for simultaneous enzymatic decarboxylation of L-glutamic acid to GABA (33% conversion) and further separation of L-aspartic acid and unconverted L-glutamic acid from GABA was successful leading to current efficiency of 40% and low energy consumption of 3 kWh kg-1. CONCLUSIONS Together with the high mechanical stability obtained for the MMMs, this opens the route towards process intensification, combining enzymatic conversion and separation with electrodialysis in one integrated process for the successful isolation of amino acids for biorefinery applications. © 2013 Society of Chemical Industry
Original languageEnglish
Pages (from-to)425-435
JournalJournal of chemical technology and biotechnology
Volume89
Issue number3
DOIs
Publication statusPublished - 5 Jul 2014

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Electrodialysis
Amino acids
Membranes
Acids
Mechanical stability
Fractionation
Energy utilization
Enzymes

Keywords

  • METIS-300376
  • IR-88505

Cite this

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title = "Mixed matrix membranes for process intensification in electrodialysis of amino acids",
abstract = "BACKGROUND Amino acids are valuable intermediates in the biobased economy for the production of chemicals. Electro-membrane processes combined with enzymatic modification have been investigated as an alternative technology for the fractionation of a mixture of amino acids with almost identical charge behavior. Up to now, the modification and subsequent separation were performed in two separate reactors. An interesting approach is the integration of both unit operations into one single device using mixed matrix membranes (MMMs) as platform for enzymatic conversion. RESULTS MMMs containing the enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) Relizyme EP403/S as carrier were prepared showing satisfactory mechanical stability and enzymatic activity for L-glutamic acid conversion into γ-aminobutyric acid (GABA). ED with integrated MMM for simultaneous enzymatic decarboxylation of L-glutamic acid to GABA (33{\%} conversion) and further separation of L-aspartic acid and unconverted L-glutamic acid from GABA was successful leading to current efficiency of 40{\%} and low energy consumption of 3 kWh kg-1. CONCLUSIONS Together with the high mechanical stability obtained for the MMMs, this opens the route towards process intensification, combining enzymatic conversion and separation with electrodialysis in one integrated process for the successful isolation of amino acids for biorefinery applications. {\circledC} 2013 Society of Chemical Industry",
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author = "{Kattan Readi}, O.M. and Rolevink, {Hendrikus H.M.} and Nijmeijer, {Dorothea C.}",
year = "2014",
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doi = "10.1002/jctb.4135",
language = "English",
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}

Mixed matrix membranes for process intensification in electrodialysis of amino acids. / Kattan Readi, O.M.; Rolevink, Hendrikus H.M.; Nijmeijer, Dorothea C.

In: Journal of chemical technology and biotechnology, Vol. 89, No. 3, 05.07.2014, p. 425-435.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Mixed matrix membranes for process intensification in electrodialysis of amino acids

AU - Kattan Readi, O.M.

AU - Rolevink, Hendrikus H.M.

AU - Nijmeijer, Dorothea C.

PY - 2014/7/5

Y1 - 2014/7/5

N2 - BACKGROUND Amino acids are valuable intermediates in the biobased economy for the production of chemicals. Electro-membrane processes combined with enzymatic modification have been investigated as an alternative technology for the fractionation of a mixture of amino acids with almost identical charge behavior. Up to now, the modification and subsequent separation were performed in two separate reactors. An interesting approach is the integration of both unit operations into one single device using mixed matrix membranes (MMMs) as platform for enzymatic conversion. RESULTS MMMs containing the enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) Relizyme EP403/S as carrier were prepared showing satisfactory mechanical stability and enzymatic activity for L-glutamic acid conversion into γ-aminobutyric acid (GABA). ED with integrated MMM for simultaneous enzymatic decarboxylation of L-glutamic acid to GABA (33% conversion) and further separation of L-aspartic acid and unconverted L-glutamic acid from GABA was successful leading to current efficiency of 40% and low energy consumption of 3 kWh kg-1. CONCLUSIONS Together with the high mechanical stability obtained for the MMMs, this opens the route towards process intensification, combining enzymatic conversion and separation with electrodialysis in one integrated process for the successful isolation of amino acids for biorefinery applications. © 2013 Society of Chemical Industry

AB - BACKGROUND Amino acids are valuable intermediates in the biobased economy for the production of chemicals. Electro-membrane processes combined with enzymatic modification have been investigated as an alternative technology for the fractionation of a mixture of amino acids with almost identical charge behavior. Up to now, the modification and subsequent separation were performed in two separate reactors. An interesting approach is the integration of both unit operations into one single device using mixed matrix membranes (MMMs) as platform for enzymatic conversion. RESULTS MMMs containing the enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) Relizyme EP403/S as carrier were prepared showing satisfactory mechanical stability and enzymatic activity for L-glutamic acid conversion into γ-aminobutyric acid (GABA). ED with integrated MMM for simultaneous enzymatic decarboxylation of L-glutamic acid to GABA (33% conversion) and further separation of L-aspartic acid and unconverted L-glutamic acid from GABA was successful leading to current efficiency of 40% and low energy consumption of 3 kWh kg-1. CONCLUSIONS Together with the high mechanical stability obtained for the MMMs, this opens the route towards process intensification, combining enzymatic conversion and separation with electrodialysis in one integrated process for the successful isolation of amino acids for biorefinery applications. © 2013 Society of Chemical Industry

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