Mixed matrix membranes for toxin removal from blood

M.S.L. Tijink, J. Sun, O. ter Beek, S. Saiful, Z. Borneman, M. Wessling, D.F. Stamatialis

Research output: Contribution to journalMeeting AbstractAcademic

Abstract

Objectives: Chronic kidney failure requires an artificial kidney treatment called hemodialysis. However, not all uremic toxins can be removed from the blood by dialysis and therefore morbidity and mortality of patients are still high. In this work we develop a Mixed Matrix Membrane (MMM) which consists of adsorptive particles imbedded into a porous polymer matrix for selective adsorption and removal of uremic toxins from blood, combining diffusion and adsorption in one step. A particle-free layer is also introduced on the blood contacting side of the MMM to prevent biocompatibility problems caused by direct blood contact with the adsorbent.

Methods: Polyethersulfone based porous MMM with activated carbon particles and a particle-free top layer were prepared by co-casting and subsequent liquid-liquid phase separation. The membranes were characterized by scanning electron microscopy, clean water flux measurements and adsorption capacity experiments with blood model solutions.

Results: Mixed Matrix Membranes with homogenous distribution of carbon particles and with a high clean water permeability were developed. Creatinine, a small uremic toxin, was selectively removed from a blood model solution both via diffusion as well as adsorption by the MMM.

Conclusions: This study shows a proof of principle for Mixed Matrix Membranes as an artificial kidney treatment. The MMM selectively removes toxins via both diffusion and adsorption in one step.
Original languageEnglish
Pages (from-to)460-460
JournalInternational journal of artificial organs
Volume33
Issue number7
Publication statusPublished - 23 Jul 2011
EventXXXVII Annual ESAO Congress 2010 - Skopje, Macedonia, The Former Yugoslav Republic of
Duration: 8 Sep 201011 Sep 2010
Conference number: 37th

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Blood
Membranes
Adsorption
Artificial Kidneys
Carbon
Dialysis
Water
Liquids
Polymer matrix
Biocompatibility
Phase separation
Electron Scanning Microscopy
Activated carbon
Adsorbents
Chronic Kidney Failure
Renal Dialysis
Permeability
Creatinine
Polymers
Casting

Cite this

Tijink, M. S. L., Sun, J., ter Beek, O., Saiful, S., Borneman, Z., Wessling, M., & Stamatialis, D. F. (2011). Mixed matrix membranes for toxin removal from blood. International journal of artificial organs, 33(7), 460-460.
Tijink, M.S.L. ; Sun, J. ; ter Beek, O. ; Saiful, S. ; Borneman, Z. ; Wessling, M. ; Stamatialis, D.F. / Mixed matrix membranes for toxin removal from blood. In: International journal of artificial organs. 2011 ; Vol. 33, No. 7. pp. 460-460.
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Tijink, MSL, Sun, J, ter Beek, O, Saiful, S, Borneman, Z, Wessling, M & Stamatialis, DF 2011, 'Mixed matrix membranes for toxin removal from blood' International journal of artificial organs, vol. 33, no. 7, pp. 460-460.

Mixed matrix membranes for toxin removal from blood. / Tijink, M.S.L.; Sun, J.; ter Beek, O.; Saiful, S.; Borneman, Z.; Wessling, M.; Stamatialis, D.F.

In: International journal of artificial organs, Vol. 33, No. 7, 23.07.2011, p. 460-460.

Research output: Contribution to journalMeeting AbstractAcademic

TY - JOUR

T1 - Mixed matrix membranes for toxin removal from blood

AU - Tijink, M.S.L.

AU - Sun, J.

AU - ter Beek, O.

AU - Saiful, S.

AU - Borneman, Z.

AU - Wessling, M.

AU - Stamatialis, D.F.

PY - 2011/7/23

Y1 - 2011/7/23

N2 - Objectives: Chronic kidney failure requires an artificial kidney treatment called hemodialysis. However, not all uremic toxins can be removed from the blood by dialysis and therefore morbidity and mortality of patients are still high. In this work we develop a Mixed Matrix Membrane (MMM) which consists of adsorptive particles imbedded into a porous polymer matrix for selective adsorption and removal of uremic toxins from blood, combining diffusion and adsorption in one step. A particle-free layer is also introduced on the blood contacting side of the MMM to prevent biocompatibility problems caused by direct blood contact with the adsorbent.Methods: Polyethersulfone based porous MMM with activated carbon particles and a particle-free top layer were prepared by co-casting and subsequent liquid-liquid phase separation. The membranes were characterized by scanning electron microscopy, clean water flux measurements and adsorption capacity experiments with blood model solutions.Results: Mixed Matrix Membranes with homogenous distribution of carbon particles and with a high clean water permeability were developed. Creatinine, a small uremic toxin, was selectively removed from a blood model solution both via diffusion as well as adsorption by the MMM.Conclusions: This study shows a proof of principle for Mixed Matrix Membranes as an artificial kidney treatment. The MMM selectively removes toxins via both diffusion and adsorption in one step.

AB - Objectives: Chronic kidney failure requires an artificial kidney treatment called hemodialysis. However, not all uremic toxins can be removed from the blood by dialysis and therefore morbidity and mortality of patients are still high. In this work we develop a Mixed Matrix Membrane (MMM) which consists of adsorptive particles imbedded into a porous polymer matrix for selective adsorption and removal of uremic toxins from blood, combining diffusion and adsorption in one step. A particle-free layer is also introduced on the blood contacting side of the MMM to prevent biocompatibility problems caused by direct blood contact with the adsorbent.Methods: Polyethersulfone based porous MMM with activated carbon particles and a particle-free top layer were prepared by co-casting and subsequent liquid-liquid phase separation. The membranes were characterized by scanning electron microscopy, clean water flux measurements and adsorption capacity experiments with blood model solutions.Results: Mixed Matrix Membranes with homogenous distribution of carbon particles and with a high clean water permeability were developed. Creatinine, a small uremic toxin, was selectively removed from a blood model solution both via diffusion as well as adsorption by the MMM.Conclusions: This study shows a proof of principle for Mixed Matrix Membranes as an artificial kidney treatment. The MMM selectively removes toxins via both diffusion and adsorption in one step.

M3 - Meeting Abstract

VL - 33

SP - 460

EP - 460

JO - International journal of artificial organs

JF - International journal of artificial organs

SN - 0391-3988

IS - 7

ER -

Tijink MSL, Sun J, ter Beek O, Saiful S, Borneman Z, Wessling M et al. Mixed matrix membranes for toxin removal from blood. International journal of artificial organs. 2011 Jul 23;33(7):460-460.