Model studies toward trivalent cation binding by appropriately functionalized calix[4]arenes

M.H.B. Grote gansey, Marcel H.B. Grote Gansey, Willem Verboom, F.C.J.M. van Veggel, Victor Vetrogon, Françoise Arnaud-Neu, Marie-José Schwing-Weill, David Reinhoudt

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Abstract

Molecular modeling and molecular dynamics of a series of calix[4]arene tetracarboxylic acids and tricarboxylic acid monoamides revealed that in an aqueous environment the phenolic oxygen atoms do not participate in the complexation of Ac3+. This observation led to the design and synthesis of new calix[4]arene based ionophores, containing multiple glycine units, having an increased number of potential donor sites. Potentiometric titrations in methanol with La3+ as a non-radioactive model for Ac3+ indicated that, although the level of complexation is high for all ligands, a new calix[4]arene derivative 5 is superior at pH < 4.
Original languageUndefined
Pages (from-to)2351-2360
JournalJournal of the Chemical Society. Perkin transactions II
Volume1998
Issue number11
DOIs
Publication statusPublished - 1998

Keywords

  • METIS-105976
  • IR-11064

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