Modeling and simulation of deep brain stimulation in Parkinson's disease

Tjitske Heida, R. Moroney, Enrico Marani, K.G. Usunoff

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    Abstract

    Deep Brain Stimulation (DBS) is effective in the Parkinsonian state, while it seems to produce rather non-selective stimulation over an unknown volume of tissue. Despite a huge amount of anatomical and physiological data regarding the structure of the basal ganglia (BG) and their connections, the computational processes performed by the basal ganglia in health and disease still remain unclear. Its hypothesized roles are discussed in this chapter as well as the changes that are observed under pathophysiological conditions. Several hypotheses exist in explaining the mechanism by which DBS provides its beneficial effects. Computational models of the BG span a range of structural levels, from low-level membrane conductance-based models of single neurons to high level system models of the complete BG circuit. A selection of models is presented in this chapter. This chapter aims at explaining how models of neurons and connected brain nuclei contribute to the understanding of DBS.
    Original languageUndefined
    Title of host publicationBiomedical Diagnostics and Clinical Technologies: Applying High-Performance Cluster and Grid Computing
    EditorsM. Pereira, M. Freire
    Place of PublicationPortugal
    PublisherMedical Information Science Reference
    Pages62-120
    Number of pages1
    ISBN (Print)978-1-60566-280-0
    DOIs
    Publication statusPublished - 1 Mar 2009

    Publication series

    NamePremier Reference Source
    PublisherMedical Information Science Reference

    Keywords

    • Deep Brain Stimulation
    • IR-75106
    • Parkinson's Disease
    • BSS-Electrical Neurostimulation
    • EWI-17629
    • METIS-275572

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