Modeling and simulation of deep brain stimulation in Parkinson's disease

Tjitske Heida; R. Moroney; Enrico Marani; K.G. Usunoff

doi:10.4018/978-1-60566-280-0.ch003

Modeling and simulation of deep brain stimulation in Parkinson's disease

Tjitske Heida, R. Moroney, Enrico Marani, K.G. Usunoff

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Deep Brain Stimulation (DBS) is effective in the Parkinsonian state, while it seems to produce rather non-selective stimulation over an unknown volume of tissue. Despite a huge amount of anatomical and physiological data regarding the structure of the basal ganglia (BG) and their connections, the computational processes performed by the basal ganglia in health and disease still remain unclear. Its hypothesized roles are discussed in this chapter as well as the changes that are observed under pathophysiological conditions. Several hypotheses exist in explaining the mechanism by which DBS provides its beneficial effects. Computational models of the BG span a range of structural levels, from low-level membrane conductance-based models of single neurons to high level system models of the complete BG circuit. A selection of models is presented in this chapter. This chapter aims at explaining how models of neurons and connected brain nuclei contribute to the understanding of DBS.

Original language	Undefined
Title of host publication	Biomedical Diagnostics and Clinical Technologies: Applying High-Performance Cluster and Grid Computing
Editors	M. Pereira, M. Freire
Place of Publication	Portugal
Publisher	Medical Information Science Reference
Pages	62-120
Number of pages	1
ISBN (Print)	978-1-60566-280-0
DOIs	https://doi.org/10.4018/978-1-60566-280-0.ch003
Publication status	Published - 1 Mar 2009

Publication series

Name	Premier Reference Source
Publisher	Medical Information Science Reference

Keywords

Deep Brain Stimulation
IR-75106
Parkinson's Disease
BSS-Electrical Neurostimulation
EWI-17629
METIS-275572

Access to Document

10.4018/978-1-60566-280-0.ch003

http://eprints.eemcs.utwente.nl/secure2/17629/01/Book_chapter_DBS_Heida_Moroney_Usunoff_Marani_171108_hda.pdf

Cite this

Heida, T., Moroney, R., Marani, E., & Usunoff, K. G. (2009). Modeling and simulation of deep brain stimulation in Parkinson's disease. In M. Pereira, & M. Freire (Eds.), Biomedical Diagnostics and Clinical Technologies: Applying High-Performance Cluster and Grid Computing (pp. 62-120). (Premier Reference Source). Medical Information Science Reference. https://doi.org/10.4018/978-1-60566-280-0.ch003

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Heida, T, Moroney, R, Marani, E & Usunoff, KG 2009, Modeling and simulation of deep brain stimulation in Parkinson's disease. in M Pereira & M Freire (eds), Biomedical Diagnostics and Clinical Technologies: Applying High-Performance Cluster and Grid Computing. Premier Reference Source, Medical Information Science Reference, Portugal, pp. 62-120. https://doi.org/10.4018/978-1-60566-280-0.ch003

Modeling and simulation of deep brain stimulation in Parkinson's disease. / Heida, Tjitske; Moroney, R.; Marani, Enrico et al.

Biomedical Diagnostics and Clinical Technologies: Applying High-Performance Cluster and Grid Computing. ed. / M. Pereira; M. Freire. Portugal : Medical Information Science Reference, 2009. p. 62-120 (Premier Reference Source).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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Heida T, Moroney R, Marani E, Usunoff KG. Modeling and simulation of deep brain stimulation in Parkinson's disease. In Pereira M, Freire M, editors, Biomedical Diagnostics and Clinical Technologies: Applying High-Performance Cluster and Grid Computing. Portugal: Medical Information Science Reference. 2009. p. 62-120. (Premier Reference Source). doi: 10.4018/978-1-60566-280-0.ch003