Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

Willemien Wallinga; Maarten Vliek; Eduard D. Wienk; Martin J. Alberink; Dirk L. Ypey

doi:10.1109/IEMBS.1996.646315

Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

Willemien Wallinga, Maarten Vliek, Eduard D. Wienk, Martin J. Alberink, Dirk L. Ypey

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

The membrane models of Cannon et al. (1993) and Alberink et al. (1995) for mammalian skeletal muscle fibers are based upon Hodgkin-Huxley descriptions of sodium, potassium delayed rectifier and leak conductances and the capacitive current taking into account fast inactivation of sodium channels. Now inward rectifier and chloride ion currents, sodium-potassium pump and slow inactivation of sodium channels have been inserted. The behavior of the model with respect to resting membrane potential and action potential firing does not differ remarkably from Alberink et al. The model has been used to study the removal of potassium from the T-tubular space. The inward rectifier current significantly contributes to the restoration of the normal potassium concentration after prolonged action potential firing. This may be an important mechanism to avoid muscle fatigue

Original language	English
Title of host publication	Proceedings 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1996
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	1909-1910
Number of pages	2
Volume	5
ISBN (Print)	0-7803-3811-1
DOIs	https://doi.org/10.1109/IEMBS.1996.646315
Publication status	Published - 31 Oct 1996
Event	18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996: Bridging Disciplines for Biomedicine - Amsterdam, Netherlands Duration: 31 Oct 1996 → 3 Nov 1996 Conference number: 18

Conference

Conference	18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996
Abbreviated title	EMBC
Country/Territory	Netherlands
City	Amsterdam
Period	31/10/96 → 3/11/96

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Wallinga1996modelingFinal published version, 211 KB

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@inproceedings{f78501e17f1d436ea57293f5e89bb406,

title = "Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels",

abstract = "The membrane models of Cannon et al. (1993) and Alberink et al. (1995) for mammalian skeletal muscle fibers are based upon Hodgkin-Huxley descriptions of sodium, potassium delayed rectifier and leak conductances and the capacitive current taking into account fast inactivation of sodium channels. Now inward rectifier and chloride ion currents, sodium-potassium pump and slow inactivation of sodium channels have been inserted. The behavior of the model with respect to resting membrane potential and action potential firing does not differ remarkably from Alberink et al. The model has been used to study the removal of potassium from the T-tubular space. The inward rectifier current significantly contributes to the restoration of the normal potassium concentration after prolonged action potential firing. This may be an important mechanism to avoid muscle fatigue",

author = "Willemien Wallinga and Maarten Vliek and Wienk, {Eduard D.} and Alberink, {Martin J.} and Ypey, {Dirk L.}",

year = "1996",

month = oct,

day = "31",

doi = "10.1109/IEMBS.1996.646315",

language = "English",

isbn = "0-7803-3811-1",

volume = "5",

pages = "1909--1910",

booktitle = "Proceedings 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1996",

publisher = "IEEE",

address = "United States",

note = "18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996 : Bridging Disciplines for Biomedicine, EMBC ; Conference date: 31-10-1996 Through 03-11-1996",

}

Wallinga, W, Vliek, M, Wienk, ED, Alberink, MJ & Ypey, DL 1996, Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels. in Proceedings 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1996. vol. 5, IEEE, Piscataway, NJ, pp. 1909-1910, 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996, Amsterdam, Netherlands, 31/10/96. https://doi.org/10.1109/IEMBS.1996.646315

Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels. / Wallinga, Willemien; Vliek, Maarten; Wienk, Eduard D. et al.
Proceedings 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1996. Vol. 5 Piscataway, NJ: IEEE, 1996. p. 1909-1910.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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T1 - Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

AU - Wallinga, Willemien

AU - Vliek, Maarten

AU - Wienk, Eduard D.

AU - Alberink, Martin J.

AU - Ypey, Dirk L.

N1 - Conference code: 18

PY - 1996/10/31

Y1 - 1996/10/31

N2 - The membrane models of Cannon et al. (1993) and Alberink et al. (1995) for mammalian skeletal muscle fibers are based upon Hodgkin-Huxley descriptions of sodium, potassium delayed rectifier and leak conductances and the capacitive current taking into account fast inactivation of sodium channels. Now inward rectifier and chloride ion currents, sodium-potassium pump and slow inactivation of sodium channels have been inserted. The behavior of the model with respect to resting membrane potential and action potential firing does not differ remarkably from Alberink et al. The model has been used to study the removal of potassium from the T-tubular space. The inward rectifier current significantly contributes to the restoration of the normal potassium concentration after prolonged action potential firing. This may be an important mechanism to avoid muscle fatigue

AB - The membrane models of Cannon et al. (1993) and Alberink et al. (1995) for mammalian skeletal muscle fibers are based upon Hodgkin-Huxley descriptions of sodium, potassium delayed rectifier and leak conductances and the capacitive current taking into account fast inactivation of sodium channels. Now inward rectifier and chloride ion currents, sodium-potassium pump and slow inactivation of sodium channels have been inserted. The behavior of the model with respect to resting membrane potential and action potential firing does not differ remarkably from Alberink et al. The model has been used to study the removal of potassium from the T-tubular space. The inward rectifier current significantly contributes to the restoration of the normal potassium concentration after prolonged action potential firing. This may be an important mechanism to avoid muscle fatigue

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DO - 10.1109/IEMBS.1996.646315

M3 - Conference contribution

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SP - 1909

EP - 1910

BT - Proceedings 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1996

PB - IEEE

CY - Piscataway, NJ

T2 - 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996

Y2 - 31 October 1996 through 3 November 1996

ER -

Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

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