Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

Willemien Wallinga, Maarten Vliek, Eduard D. Wienk, Martin J. Alberink, Dirk L. Ypey

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    Abstract

    The membrane models of Cannon et al. (1993) and Alberink et al. (1995) for mammalian skeletal muscle fibers are based upon Hodgkin-Huxley descriptions of sodium, potassium delayed rectifier and leak conductances and the capacitive current taking into account fast inactivation of sodium channels. Now inward rectifier and chloride ion currents, sodium-potassium pump and slow inactivation of sodium channels have been inserted. The behavior of the model with respect to resting membrane potential and action potential firing does not differ remarkably from Alberink et al. The model has been used to study the removal of potassium from the T-tubular space. The inward rectifier current significantly contributes to the restoration of the normal potassium concentration after prolonged action potential firing. This may be an important mechanism to avoid muscle fatigue
    Original languageEnglish
    Title of host publicationProceedings 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1996
    Place of PublicationPiscataway, NJ
    PublisherIEEE
    Pages1909-1910
    Number of pages2
    Volume5
    ISBN (Print)0-7803-3811-1
    DOIs
    Publication statusPublished - 31 Oct 1996
    Event18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996: Bridging Disciplines for Biomedicine - Amsterdam, Netherlands
    Duration: 31 Oct 19963 Nov 1996
    Conference number: 18

    Conference

    Conference18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996
    Abbreviated titleEMBC
    CountryNetherlands
    CityAmsterdam
    Period31/10/963/11/96

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  • Cite this

    Wallinga, W., Vliek, M., Wienk, E. D., Alberink, M. J., & Ypey, D. L. (1996). Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels. In Proceedings 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1996 (Vol. 5, pp. 1909-1910). Piscataway, NJ: IEEE. https://doi.org/10.1109/IEMBS.1996.646315