Abstract
Hepatocellular carcinoma (HCC) is a leading cause of mortality worldwide. There is yet no effective therapy available for advanced HCC. A major limitation to develop therapeutic treatments is the lack of accurate in vitro models recapitulating key-features of this disease. Here, we report a co-culture spheroid model combining human hepatic stellate cells and hepatocytes, which are the key cell types involved in HCC development. This model emulates HCC pathological features, such as a collagen-rich fibrotic capsule, acting as a barrier for drug delivery.
Original language | English |
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Title of host publication | Proceedings of MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
Publisher | The Chemical and Biological Microsystems Society |
Pages | 937-938 |
Number of pages | 2 |
ISBN (Electronic) | 9781733419017 |
Publication status | Published - 2020 |
Event | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event Duration: 4 Oct 2020 → 9 Oct 2020 Conference number: 24 https://microtas2020.org/ |
Publication series
Name | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
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Conference
Conference | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 |
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Abbreviated title | MicroTAS 2020 |
City | Virtual Event |
Period | 4/10/20 → 9/10/20 |
Internet address |
Keywords
- (Nano)-Therapeutics
- Hepatocellular Carcinoma
- Multi-Cellular Tumor Spheroids
- Stroma