Modelling the tumor micro-environment in hepatocellular carcinoma using multi-cellular spheroids

Ana Ortiz-Perez, Agnieszka Zuchowska, Jean Baptiste Blondé, Ruchi Bansal, Séverine Le Gac*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of mortality worldwide. There is yet no effective therapy available for advanced HCC. A major limitation to develop therapeutic treatments is the lack of accurate in vitro models recapitulating key-features of this disease. Here, we report a co-culture spheroid model combining human hepatic stellate cells and hepatocytes, which are the key cell types involved in HCC development. This model emulates HCC pathological features, such as a collagen-rich fibrotic capsule, acting as a barrier for drug delivery.

Original languageEnglish
Title of host publicationProceedings of MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherThe Chemical and Biological Microsystems Society
Pages937-938
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event
Duration: 4 Oct 20209 Oct 2020
Conference number: 24
https://microtas2020.org/

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020
Abbreviated titleMicroTAS 2020
CityVirtual Event
Period4/10/209/10/20
Internet address

Keywords

  • (Nano)-Therapeutics
  • Hepatocellular Carcinoma
  • Multi-Cellular Tumor Spheroids
  • Stroma

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