Abstract
Hepatocellular carcinoma (HCC) is a leading cause of mortality worldwide. There is yet no effective therapy available for advanced HCC. A major limitation to develop therapeutic treatments is the lack of accurate in vitro models recapitulating key-features of this disease. Here, we report a co-culture spheroid model combining human hepatic stellate cells and hepatocytes, which are the key cell types involved in HCC development. This model emulates HCC pathological features, such as a collagen-rich fibrotic capsule, acting as a barrier for drug delivery.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | The Chemical and Biological Microsystems Society |
| Pages | 937-938 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419017 |
| Publication status | Published - 2020 |
| Event | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event Duration: 4 Oct 2020 → 9 Oct 2020 Conference number: 24 https://microtas2020.org/ |
Publication series
| Name | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 |
|---|---|
| Abbreviated title | MicroTAS 2020 |
| City | Virtual Event |
| Period | 4/10/20 → 9/10/20 |
| Internet address |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- (Nano)-Therapeutics
- Hepatocellular Carcinoma
- Multi-Cellular Tumor Spheroids
- Stroma
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