Modular ATR FT-IR microreactor chip for optimizing reaction conditions

Jasper J.A. Lozeman; Jeroen C. Vollenbroek; Johan G. Bomer; Hans L. de Boer; Albert  van den Berg; Mathieu  Odijk

Modular ATR FT-IR microreactor chip for optimizing reaction conditions

Jasper J.A. Lozeman, Jeroen C. Vollenbroek, Johan G. Bomer, Hans L. de Boer, Albert van den Berg, Mathieu Odijk

Biomedical and Environmental Sensorsystems

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

188 Downloads (Pure)

Abstract

A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

Original language	English
Title of host publication	MicroTAS 2018
Subtitle of host publication	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Editors	Fan-Gang Tseng, Gwo-Bin Lee
Publisher	The Chemical and Biological Microsystems Society
Pages	2117-2120
Number of pages	4
ISBN (Electronic)	978-1-510-89757-1
ISBN (Print)	978-0-578-40530-8
Publication status	Published - 11 Nov 2018
Event	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan Duration: 10 Nov 2018 → 15 Nov 2018 Conference number: 22 https://cbmsociety.org/conferences/microtas2018/

Conference

Conference	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated title	MicroTAS 2018
Country/Territory	Taiwan
City	Kaohsiung
Period	10/11/18 → 15/11/18
Internet address	https://cbmsociety.org/conferences/microtas2018/

Keywords

2019 OA procedure
Attenuated total reflection
Online reaction monitoring
Infrared spectroscopy

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Lozeman2018modularFinal published version, 888 KBLicence: Taverne

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Lozeman, J. J. A., Vollenbroek, J. C., Bomer, J. G., de Boer, H. L., van den Berg, A., & Odijk, M. (2018). Modular ATR FT-IR microreactor chip for optimizing reaction conditions. In F.-G. Tseng, & G.-B. Lee (Eds.), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2117-2120). The Chemical and Biological Microsystems Society.

@inproceedings{e2bbc5a5c8764bebbccba7b667b7d665,

title = "Modular ATR FT-IR microreactor chip for optimizing reaction conditions",

abstract = "A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.",

keywords = "2019 OA procedure, Attenuated total reflection, Online reaction monitoring, Infrared spectroscopy",

author = "Lozeman, {Jasper J.A.} and Vollenbroek, {Jeroen C.} and Bomer, {Johan G.} and {de Boer}, {Hans L.} and {van den Berg}, Albert and Mathieu Odijk",

year = "2018",

month = nov,

day = "11",

language = "English",

isbn = "978-0-578-40530-8",

pages = "2117--2120",

editor = "Fan-Gang Tseng and Gwo-Bin Lee",

booktitle = "MicroTAS 2018",

publisher = "The Chemical and Biological Microsystems Society",

note = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, MicroTAS 2018 ; Conference date: 10-11-2018 Through 15-11-2018",

url = "https://cbmsociety.org/conferences/microtas2018/",

}

Lozeman, JJA , Vollenbroek, JC , Bomer, JG, de Boer, HL, van den Berg, A & Odijk, M 2018, Modular ATR FT-IR microreactor chip for optimizing reaction conditions. in F-G Tseng & G-B Lee (eds), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, pp. 2117-2120, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, 10/11/18.

Modular ATR FT-IR microreactor chip for optimizing reaction conditions. / Lozeman, Jasper J.A.; Vollenbroek, Jeroen C.; Bomer, Johan G. et al.
MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / Fan-Gang Tseng; Gwo-Bin Lee. The Chemical and Biological Microsystems Society, 2018. p. 2117-2120.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Modular ATR FT-IR microreactor chip for optimizing reaction conditions

AU - Lozeman, Jasper J.A.

AU - Vollenbroek, Jeroen C.

AU - Bomer, Johan G.

AU - de Boer, Hans L.

AU - van den Berg, Albert

AU - Odijk, Mathieu

N1 - Conference code: 22

PY - 2018/11/11

Y1 - 2018/11/11

N2 - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

AB - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

KW - 2019 OA procedure

KW - Attenuated total reflection

KW - Online reaction monitoring

KW - Infrared spectroscopy

M3 - Conference contribution

SN - 978-0-578-40530-8

SP - 2117

EP - 2120

BT - MicroTAS 2018

A2 - Tseng, Fan-Gang

A2 - Lee, Gwo-Bin

PB - The Chemical and Biological Microsystems Society

T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018

Y2 - 10 November 2018 through 15 November 2018

ER -

Modular ATR FT-IR microreactor chip for optimizing reaction conditions

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