Modular ATR FT-IR microreactor chip for optimizing reaction conditions

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Abstract

A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.
Original languageEnglish
Title of host publicationMicroTAS 2018
Subtitle of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Pages2117-2120
Number of pages4
Publication statusPublished - 11 Nov 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China
Duration: 10 Nov 201815 Nov 2018
Conference number: 22
https://cbmsociety.org/conferences/microtas2018/

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated titleMicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period10/11/1815/11/18
Internet address

Fingerprint

Hexanes
Silicon
Ketones
Fourier transforms
Infrared radiation
n-butylamine
2,5-dimethylpyrrole

Keywords

  • Infrared spectroscopy
  • Attenuated total reflection
  • Online reaction monitoring

Cite this

Lozeman, J. J. A., Vollenbroek, J. C., Bomer, J. G., de Boer, H. L., van den Berg, A., & Odijk, M. (2018). Modular ATR FT-IR microreactor chip for optimizing reaction conditions. In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2117-2120)
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title = "Modular ATR FT-IR microreactor chip for optimizing reaction conditions",
abstract = "A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.",
keywords = "Infrared spectroscopy, Attenuated total reflection, Online reaction monitoring",
author = "Lozeman, {Jasper Jeroen Andr{\'e}} and Vollenbroek, {Jeroen Christiaan} and Bomer, {Johan G.} and {de Boer}, {Hans L.} and {van den Berg}, Albert and Mathieu Odijk",
year = "2018",
month = "11",
day = "11",
language = "English",
isbn = "978-0-578-40530-8",
pages = "2117--2120",
booktitle = "MicroTAS 2018",

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Lozeman, JJA, Vollenbroek, JC, Bomer, JG, de Boer, HL, van den Berg, A & Odijk, M 2018, Modular ATR FT-IR microreactor chip for optimizing reaction conditions. in MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. pp. 2117-2120, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, Province of China, 10/11/18.

Modular ATR FT-IR microreactor chip for optimizing reaction conditions. / Lozeman, Jasper Jeroen André; Vollenbroek, Jeroen Christiaan; Bomer, Johan G.; de Boer, Hans L.; van den Berg, Albert ; Odijk, Mathieu .

MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2018. p. 2117-2120.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Modular ATR FT-IR microreactor chip for optimizing reaction conditions

AU - Lozeman, Jasper Jeroen André

AU - Vollenbroek, Jeroen Christiaan

AU - Bomer, Johan G.

AU - de Boer, Hans L.

AU - van den Berg, Albert

AU - Odijk, Mathieu

PY - 2018/11/11

Y1 - 2018/11/11

N2 - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

AB - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

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KW - Attenuated total reflection

KW - Online reaction monitoring

M3 - Conference contribution

SN - 978-0-578-40530-8

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BT - MicroTAS 2018

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Lozeman JJA, Vollenbroek JC, Bomer JG, de Boer HL, van den Berg A, Odijk M. Modular ATR FT-IR microreactor chip for optimizing reaction conditions. In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2018. p. 2117-2120