Modular ATR FT-IR microreactor chip for optimizing reaction conditions

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    Abstract

    A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.
    Original languageEnglish
    Title of host publicationMicroTAS 2018
    Subtitle of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Pages2117-2120
    Number of pages4
    Publication statusPublished - 11 Nov 2018
    Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China
    Duration: 10 Nov 201815 Nov 2018
    Conference number: 22
    https://cbmsociety.org/conferences/microtas2018/

    Conference

    Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
    Abbreviated titleMicroTAS 2018
    CountryTaiwan, Province of China
    CityKaohsiung
    Period10/11/1815/11/18
    Internet address

    Fingerprint

    Hexanes
    Silicon
    Ketones
    Fourier transforms
    Infrared radiation
    n-butylamine
    2,5-dimethylpyrrole

    Keywords

    • Infrared spectroscopy
    • Attenuated total reflection
    • Online reaction monitoring

    Cite this

    Lozeman, J. J. A., Vollenbroek, J. C., Bomer, J. G., de Boer, H. L., van den Berg, A., & Odijk, M. (2018). Modular ATR FT-IR microreactor chip for optimizing reaction conditions. In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2117-2120)
    Lozeman, Jasper Jeroen André ; Vollenbroek, Jeroen Christiaan ; Bomer, Johan G. ; de Boer, Hans L. ; van den Berg, Albert ; Odijk, Mathieu . / Modular ATR FT-IR microreactor chip for optimizing reaction conditions. MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2018. pp. 2117-2120
    @inproceedings{e2bbc5a5c8764bebbccba7b667b7d665,
    title = "Modular ATR FT-IR microreactor chip for optimizing reaction conditions",
    abstract = "A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.",
    keywords = "Infrared spectroscopy, Attenuated total reflection, Online reaction monitoring",
    author = "Lozeman, {Jasper Jeroen Andr{\'e}} and Vollenbroek, {Jeroen Christiaan} and Bomer, {Johan G.} and {de Boer}, {Hans L.} and {van den Berg}, Albert and Mathieu Odijk",
    year = "2018",
    month = "11",
    day = "11",
    language = "English",
    isbn = "978-0-578-40530-8",
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    booktitle = "MicroTAS 2018",

    }

    Lozeman, JJA, Vollenbroek, JC, Bomer, JG, de Boer, HL, van den Berg, A & Odijk, M 2018, Modular ATR FT-IR microreactor chip for optimizing reaction conditions. in MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. pp. 2117-2120, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, Province of China, 10/11/18.

    Modular ATR FT-IR microreactor chip for optimizing reaction conditions. / Lozeman, Jasper Jeroen André; Vollenbroek, Jeroen Christiaan; Bomer, Johan G.; de Boer, Hans L.; van den Berg, Albert ; Odijk, Mathieu .

    MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2018. p. 2117-2120.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    TY - GEN

    T1 - Modular ATR FT-IR microreactor chip for optimizing reaction conditions

    AU - Lozeman, Jasper Jeroen André

    AU - Vollenbroek, Jeroen Christiaan

    AU - Bomer, Johan G.

    AU - de Boer, Hans L.

    AU - van den Berg, Albert

    AU - Odijk, Mathieu

    PY - 2018/11/11

    Y1 - 2018/11/11

    N2 - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

    AB - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

    KW - Infrared spectroscopy

    KW - Attenuated total reflection

    KW - Online reaction monitoring

    M3 - Conference contribution

    SN - 978-0-578-40530-8

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    EP - 2120

    BT - MicroTAS 2018

    ER -

    Lozeman JJA, Vollenbroek JC, Bomer JG, de Boer HL, van den Berg A, Odijk M. Modular ATR FT-IR microreactor chip for optimizing reaction conditions. In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2018. p. 2117-2120