Modular ATR FT-IR microreactor chip for optimizing reaction conditions

Jasper J.A. Lozeman; Jeroen C. Vollenbroek; Johan G. Bomer; Hans L. de Boer; Albert  van den Berg; Mathieu  Odijk

Modular ATR FT-IR microreactor chip for optimizing reaction conditions

Jasper J.A. Lozeman, Jeroen C. Vollenbroek, Johan G. Bomer, Hans L. de Boer, Albert van den Berg, Mathieu Odijk

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Abstract

A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

Original language	English
Number of pages	1
Publication status	Published - 11 Nov 2018
Event	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan Duration: 10 Nov 2018 → 15 Nov 2018 Conference number: 22 https://cbmsociety.org/conferences/microtas2018/

Conference

Conference	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated title	MicroTAS 2018
Country/Territory	Taiwan
City	Kaohsiung
Period	10/11/18 → 15/11/18
Internet address	https://cbmsociety.org/conferences/microtas2018/

Keywords

Infrared spectroscopy, attenuated total reflection, online reaction monitoring

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@conference{d64a8076c18b48e99a0ed3bb72e32c7a,

title = "Modular ATR FT-IR microreactor chip for optimizing reaction conditions",

abstract = "A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.",

keywords = "Infrared spectroscopy, attenuated total reflection, online reaction monitoring",

author = "Lozeman, {Jasper J.A.} and Vollenbroek, {Jeroen C.} and Bomer, {Johan G.} and {de Boer}, {Hans L.} and {van den Berg}, Albert and Mathieu Odijk",

year = "2018",

month = nov,

day = "11",

language = "English",

note = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, MicroTAS 2018 ; Conference date: 10-11-2018 Through 15-11-2018",

url = "https://cbmsociety.org/conferences/microtas2018/",

}

TY - CONF

T1 - Modular ATR FT-IR microreactor chip for optimizing reaction conditions

AU - Lozeman, Jasper J.A.

AU - Vollenbroek, Jeroen C.

AU - Bomer, Johan G.

AU - de Boer, Hans L.

AU - van den Berg, Albert

AU - Odijk, Mathieu

N1 - Conference code: 22

PY - 2018/11/11

Y1 - 2018/11/11

N2 - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

AB - A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.

KW - Infrared spectroscopy, attenuated total reflection, online reaction monitoring

M3 - Poster

T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018

Y2 - 10 November 2018 through 15 November 2018

ER -

Modular ATR FT-IR microreactor chip for optimizing reaction conditions

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