A silicon chip for attenuated total reflection (ATR) Fourier transform infrared (FT-IR) spectroscopy in combination with a modular PDMS herringbone mixer and a microreactor has been successfully fabricated and tested. The modular design allows the chip to be used for a variety of reactions. A model synthesis of 1-butyl-2,5-dimethyl-1H-pyrrole from hexane-2,5-dione with 1-butylamine has been performed on chip. When plotting the natural logarithm of the peak area corresponding to the ketone stretch vibration at 1710cm-1, against the residence time, a linear curve can be fitted, suggesting this step to be a first order reaction.
|Number of pages||1|
|Publication status||Published - 11 Nov 2018|
|Event||22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China|
Duration: 10 Nov 2018 → 15 Nov 2018
Conference number: 22
|Conference||22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018|
|Abbreviated title||MicroTAS 2018|
|Country||Taiwan, Province of China|
|Period||10/11/18 → 15/11/18|
- Infrared spectroscopy, attenuated total reflection, online reaction monitoring
Lozeman, J. J. A., Vollenbroek, J. C., Bomer, J. G., de Boer, H. L., van den Berg, A., & Odijk, M. (2018). Modular ATR FT-IR microreactor chip for optimizing reaction conditions. Poster session presented at 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, Province of China.