Modular Single-Chain Polymer Nanoparticles in Drug Delivery

Anna Pia Pauline Kröger

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

Abstract

In this thesis, thiol-Michael addition was employed in the intramolecular crosslinking of thiol polymers to yield a variety of single-chain polymer nanoparticles (SCNPs). These polymer nanoparticles are ~10 nm in diameter, which is markedly smaller than conventional polymer nanoparticles. Furthermore, altered biodistribution behavior is anticipated, with improved targeting characteristics towards certain areas in the human body.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Grijpma, D.W., Supervisor
  • Cornelissen, Jeroen, Supervisor
  • Paulusse, J.M.J., Co-Supervisor
Award date3 Oct 2018
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-4623-2
Electronic ISBNs978-90-365-4623-2
DOIs
Publication statusPublished - 3 Oct 2018

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Drug delivery
Polymers
Nanoparticles
Sulfhydryl Compounds
Crosslinking

Cite this

Kröger, Anna Pia Pauline. / Modular Single-Chain Polymer Nanoparticles in Drug Delivery. Enschede : University of Twente, 2018. 198 p.
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Modular Single-Chain Polymer Nanoparticles in Drug Delivery. / Kröger, Anna Pia Pauline.

Enschede : University of Twente, 2018. 198 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

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AB - In this thesis, thiol-Michael addition was employed in the intramolecular crosslinking of thiol polymers to yield a variety of single-chain polymer nanoparticles (SCNPs). These polymer nanoparticles are ~10 nm in diameter, which is markedly smaller than conventional polymer nanoparticles. Furthermore, altered biodistribution behavior is anticipated, with improved targeting characteristics towards certain areas in the human body.

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