Modular Single-Chain Polymer Nanoparticles in Drug Delivery

Anna Pia Pauline Kröger

doi:10.3990/1.9789036546232

Modular Single-Chain Polymer Nanoparticles in Drug Delivery

Anna Pia Pauline Kröger

Biomolecular Nanotechnology

Research output: Thesis › PhD Thesis - Research UT, graduation UT

Abstract

In this thesis, thiol-Michael addition was employed in the intramolecular crosslinking of thiol polymers to yield a variety of single-chain polymer nanoparticles (SCNPs). These polymer nanoparticles are ~10 nm in diameter, which is markedly smaller than conventional polymer nanoparticles. Furthermore, altered biodistribution behavior is anticipated, with improved targeting characteristics towards certain areas in the human body.

Original language	English
Awarding Institution	University of Twente
Supervisors/Advisors	Grijpma, D.W., Supervisor Cornelissen, Jeroen, Supervisor Paulusse, J.M.J., Co-Supervisor
Award date	3 Oct 2018
Place of Publication	Enschede
Publisher	University of Twente
Print ISBNs	978-90-365-4623-2
Electronic ISBNs	978-90-365-4623-2
DOIs	https://doi.org/10.3990/1.9789036546232
Publication status	Published - 3 Oct 2018

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Kröger, A. P. P. (2018). Modular Single-Chain Polymer Nanoparticles in Drug Delivery. Enschede: University of Twente. https://doi.org/10.3990/1.9789036546232

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AB - In this thesis, thiol-Michael addition was employed in the intramolecular crosslinking of thiol polymers to yield a variety of single-chain polymer nanoparticles (SCNPs). These polymer nanoparticles are ~10 nm in diameter, which is markedly smaller than conventional polymer nanoparticles. Furthermore, altered biodistribution behavior is anticipated, with improved targeting characteristics towards certain areas in the human body.

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