Modulation of neuronal network activity with ghrelin

Irina Stoyanova; Wim Rutten; Jakob le Feber

Modulation of neuronal network activity with ghrelin

Irina Stoyanova, Wim Rutten, Jakob le Feber

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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Abstract

Ghrelin is a neuropeptide regulating multiple physiological processes, including high brain functions such as learning and memory formation. However, the effect of ghrelin on network activity patterns and developments has not been studied yet. Therefore, we used dissociated cortical neurons plated on multi electrode arrays (MEAs)to investigate in vitro how acute and chronic exposure to ghrelin affects neuronal activiy. We found that ghrelin application has a strong stimulatory effect on neuronal activiy, and causes a switch from synchronous to more dispersed asynchronous network firing. When chronically applied, ghrelin leads to earlier generation of "mature" activity patterns, including neuronal bursts.

Original language	Undefined
Title of host publication	8th International Meeting on Substrate-Integrated Microelectrode Arrays
Place of Publication	Reutlingen
Publisher	NMI University Tuebingen
Pages	173-174
Number of pages	2
ISBN (Print)	2194-5519
Publication status	Published - 10 Jul 2012
Event	8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 - Reutlingen, Germany Duration: 10 Jul 2012 → 13 Jul 2012 Conference number: 8

Publication series

Name	MEA Proceedings
Publisher	NMI University Tuebingen
ISSN (Print)	2194-5519

Conference

Conference	8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
Abbreviated title	MEA
Country/Territory	Germany
City	Reutlingen
Period	10/07/12 → 13/07/12

Keywords

EWI-23091
BSS-Neurotechnology and cellular engineering
METIS-296311
IR-84228
Ghrelin
neuronal network activity

Access to Document

http://eprints.eemcs.utwente.nl/secure2/23091/01/Stoyanova_modulation.pdf

Cite this

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title = "Modulation of neuronal network activity with ghrelin",

abstract = "Ghrelin is a neuropeptide regulating multiple physiological processes, including high brain functions such as learning and memory formation. However, the effect of ghrelin on network activity patterns and developments has not been studied yet. Therefore, we used dissociated cortical neurons plated on multi electrode arrays (MEAs)to investigate in vitro how acute and chronic exposure to ghrelin affects neuronal activiy. We found that ghrelin application has a strong stimulatory effect on neuronal activiy, and causes a switch from synchronous to more dispersed asynchronous network firing. When chronically applied, ghrelin leads to earlier generation of {"}mature{"} activity patterns, including neuronal bursts.",

keywords = "EWI-23091, BSS-Neurotechnology and cellular engineering, METIS-296311, IR-84228, Ghrelin, neuronal network activity",

author = "Irina Stoyanova and Wim Rutten and {le Feber}, Jakob",

year = "2012",

month = jul,

day = "10",

language = "Undefined",

isbn = "2194-5519",

series = "MEA Proceedings",

publisher = "NMI University Tuebingen",

pages = "173--174",

booktitle = "8th International Meeting on Substrate-Integrated Microelectrode Arrays",

note = "8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 ; Conference date: 10-07-2012 Through 13-07-2012",

}

Stoyanova, I, Rutten, W & le Feber, J 2012, Modulation of neuronal network activity with ghrelin. in 8th International Meeting on Substrate-Integrated Microelectrode Arrays. MEA Proceedings, NMI University Tuebingen, Reutlingen, pp. 173-174, 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012, Reutlingen, Germany, 10/07/12. <http://eprints.eemcs.utwente.nl/secure2/23091/01/Stoyanova_modulation.pdf>

TY - GEN

T1 - Modulation of neuronal network activity with ghrelin

AU - Stoyanova, Irina

AU - Rutten, Wim

AU - le Feber, Jakob

N1 - Conference code: 8

PY - 2012/7/10

Y1 - 2012/7/10

N2 - Ghrelin is a neuropeptide regulating multiple physiological processes, including high brain functions such as learning and memory formation. However, the effect of ghrelin on network activity patterns and developments has not been studied yet. Therefore, we used dissociated cortical neurons plated on multi electrode arrays (MEAs)to investigate in vitro how acute and chronic exposure to ghrelin affects neuronal activiy. We found that ghrelin application has a strong stimulatory effect on neuronal activiy, and causes a switch from synchronous to more dispersed asynchronous network firing. When chronically applied, ghrelin leads to earlier generation of "mature" activity patterns, including neuronal bursts.

AB - Ghrelin is a neuropeptide regulating multiple physiological processes, including high brain functions such as learning and memory formation. However, the effect of ghrelin on network activity patterns and developments has not been studied yet. Therefore, we used dissociated cortical neurons plated on multi electrode arrays (MEAs)to investigate in vitro how acute and chronic exposure to ghrelin affects neuronal activiy. We found that ghrelin application has a strong stimulatory effect on neuronal activiy, and causes a switch from synchronous to more dispersed asynchronous network firing. When chronically applied, ghrelin leads to earlier generation of "mature" activity patterns, including neuronal bursts.

KW - EWI-23091

KW - BSS-Neurotechnology and cellular engineering

KW - METIS-296311

KW - IR-84228

KW - Ghrelin

KW - neuronal network activity

M3 - Conference contribution

SN - 2194-5519

T3 - MEA Proceedings

SP - 173

EP - 174

BT - 8th International Meeting on Substrate-Integrated Microelectrode Arrays

PB - NMI University Tuebingen

CY - Reutlingen

T2 - 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012

Y2 - 10 July 2012 through 13 July 2012

ER -