Modulation of neuronal network activity with ghrelin

Irina Stoyanova, Wim Rutten, Jakob le Feber

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

    Abstract

    Ghrelin is a neuropeptide regulating multiple physiological processes, including high brain functions such as learning and memory formation. However, the effect of ghrelin on network activity patterns and developments has not been studied yet. Therefore, we used dissociated cortical neurons plated on multi electrode arrays (MEAs)to investigate in vitro how acute and chronic exposure to ghrelin affects neuronal activiy. We found that ghrelin application has a strong stimulatory effect on neuronal activiy, and causes a switch from synchronous to more dispersed asynchronous network firing. When chronically applied, ghrelin leads to earlier generation of "mature" activity patterns, including neuronal bursts.
    Original languageUndefined
    Title of host publication8th International Meeting on Substrate-Integrated Microelectrode Arrays
    Place of PublicationReutlingen
    PublisherNMI University Tuebingen
    Pages173-174
    Number of pages2
    ISBN (Print)2194-5519
    Publication statusPublished - 10 Jul 2012
    Event8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 - Reutlingen, Germany
    Duration: 10 Jul 201213 Jul 2012
    Conference number: 8

    Publication series

    NameMEA Proceedings
    PublisherNMI University Tuebingen
    ISSN (Print)2194-5519

    Conference

    Conference8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
    Abbreviated titleMEA
    CountryGermany
    CityReutlingen
    Period10/07/1213/07/12

    Keywords

    • EWI-23091
    • BSS-Neurotechnology and cellular engineering
    • METIS-296311
    • IR-84228
    • Ghrelin
    • neuronal network activity

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