Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

Federica Cioffi, Rayan Hassan Ibrahim Adam, Kerensa Broersen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)
12 Downloads (Pure)

Abstract

Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-β deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.

Original languageEnglish
Pages (from-to)981-1017
Number of pages37
JournalJournal of Alzheimer's Disease
Volume72
Issue number4
DOIs
Publication statusPublished - 12 Dec 2019

Keywords

  • UT-Hybrid-D
  • amyloid-β
  • genetic factors
  • neurodegeneration
  • oxidative stress
  • reactive oxygen species
  • tau
  • Alzheimer's disease

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