Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-β deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.
|Number of pages||37|
|Journal||Journal of Alzheimer's Disease|
|Publication status||Published - 12 Dec 2019|
- genetic factors
- oxidative stress
- reactive oxygen species
- Alzheimer's disease