Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

Federica Cioffi; Rayan Hassan Ibrahim Adam; Kerensa Broersen

doi:10.3233/JAD-190863

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

Federica Cioffi, Rayan Hassan Ibrahim Adam, Kerensa Broersen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

81 Citations (Scopus)

57 Downloads (Pure)

Abstract

Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-β deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.

Original language	English
Pages (from-to)	981-1017
Number of pages	37
Journal	Journal of Alzheimer's Disease
Volume	72
Issue number	4
DOIs	https://doi.org/10.3233/JAD-190863
Publication status	Published - 12 Dec 2019

Keywords

UT-Hybrid-D
amyloid-β
genetic factors
neurodegeneration
oxidative stress
reactive oxygen species
tau
Alzheimer's disease

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10.3233/JAD-190863Licence: CC BY-NC

jad_2019_72-4_jad-72-4-jad190863_jad-72-jad190863Final published version, 343 KBLicence: CC BY-NC

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AU - Broersen, Kerensa

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N2 - Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-β deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.

AB - Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-β deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.

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KW - amyloid-β

KW - genetic factors

KW - neurodegeneration

KW - oxidative stress

KW - reactive oxygen species

KW - tau

KW - Alzheimer's disease

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Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

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