Molecular printboards as a general platform for protein immobilization: A supramolecular solution to nonspecific adsorption

M.J.W. Ludden, A. Mulder, Robert Tampe, David Reinhoudt, Jurriaan Huskens

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Be specific: A supramolecular adsorbate consisting of an adamantyl group (red) and an oligo(ethylene glycol) chain has been designed to prevent nonspecific protein adsorption at cyclodextrin molecular printboards. The adamantyl group allows specific and reversible interactions. Specific immobilization of proteins (gray) is possible through multivalent orthogonal linkers by effective replacement of the monovalent adsorbate (Ni2+ ions (green) may be needed; see picture).
Original languageUndefined
Pages (from-to)4104-4107
Number of pages4
JournalAngewandte Chemie, International Edition in English
Issue number22
Publication statusPublished - 2007


  • IR-72203
  • Cyclodextrins
  • Host-guest systems
  • METIS-241442
  • Noncovalent interactions
  • Self-assembled monolayers

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