Molecular printboards as a general platform for protein immobilization: A supramolecular solution to nonspecific adsorption

M.J.W. Ludden; A. Mulder; Robert Tampe; David Reinhoudt; Jurriaan Huskens

doi:10.1002/anie.200605104

Molecular printboards as a general platform for protein immobilization: A supramolecular solution to nonspecific adsorption

M.J.W. Ludden, A. Mulder, Robert Tampe, David Reinhoudt, Jurriaan Huskens

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Be specific: A supramolecular adsorbate consisting of an adamantyl group (red) and an oligo(ethylene glycol) chain has been designed to prevent nonspecific protein adsorption at cyclodextrin molecular printboards. The adamantyl group allows specific and reversible interactions. Specific immobilization of proteins (gray) is possible through multivalent orthogonal linkers by effective replacement of the monovalent adsorbate (Ni2+ ions (green) may be needed; see picture).

Original language	Undefined
Pages (from-to)	4104-4107
Number of pages	4
Journal	Angewandte Chemie, International Edition in English
Volume	46
Issue number	22
DOIs	https://doi.org/10.1002/anie.200605104
Publication status	Published - 2007

Keywords

IR-72203
Cyclodextrins
Host-guest systems
METIS-241442
PROTEINS
Noncovalent interactions
Self-assembled monolayers

Access to Document

10.1002/anie.200605104

Cite this

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abstract = "Be specific: A supramolecular adsorbate consisting of an adamantyl group (red) and an oligo(ethylene glycol) chain has been designed to prevent nonspecific protein adsorption at cyclodextrin molecular printboards. The adamantyl group allows specific and reversible interactions. Specific immobilization of proteins (gray) is possible through multivalent orthogonal linkers by effective replacement of the monovalent adsorbate (Ni2+ ions (green) may be needed; see picture).",

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AU - Mulder, A.

AU - Tampe, Robert

AU - Reinhoudt, David

AU - Huskens, Jurriaan

PY - 2007

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KW - IR-72203

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KW - Host-guest systems

KW - METIS-241442

KW - PROTEINS

KW - Noncovalent interactions

KW - Self-assembled monolayers

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