Molecular printboards as general platforms for protein immobilization

Manon Julia Wilhelmina Ludden

Research output: ThesisPhD Thesis - Research UT, graduation UT

165 Downloads (Pure)


This thesis describes the selective attachment of proteins to β-cyclodextrin (βCD) self-assembled monolayers (SAMs), termed molecular printboards through multivalent orthogonal interactions. It is shown that the molecular printboards allow different assembly pathways for the build-up of (complex) bionanostructures. In the assembly of these bionanostructures, control over stability, stoichiometry of binding, and orientation is achieved. A monovalent supramolecular blocking agent can be applied to prevent nonspecific immobilization of proteins to the molecular printboard, while the specific attachment of proteins via multivalent interactions is still possible.
Original languageEnglish
Awarding Institution
  • University of Twente
  • Huskens, Jurriaan, Supervisor
  • Reinhoudt, David N., Supervisor
Award date21 Sept 2007
Place of PublicationEnschede
Print ISBNs978-90-365-2521-3
Publication statusPublished - 21 Sept 2007


  • IR-58008


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