Monitoring radiofrequency ablation of biological tissue using broadband time-resolved diffuse optical spectroscopy

Pranav Lanka, K. J. Francis, Hindrik Kruit, Sanathana Konugolu Venkata Sekar, A. Farina, Rinaldo Cubeddu, Srirang Manohar, Antonio Pifferi

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)
140 Downloads (Pure)


Radiofrequency ablation (RFA) is minimally invasive thermotherapy, where a heating source is used to target and kill malignant cells in a tissue. While RFA has tremendous potential in the field of oncology, there is also a need for reliable real-time monitoring of this procedure to avoid over or under treatment. In this work, we investigate the use of timeresolved diffuse optical spectroscopy (DOS) to continuously track the change in optical properties during RFA to monitor the process of ablation. The time evolution of the spectra of the optical properties of the tissue undergoing treatment gives deep insights into the structural and constitutional changes occurring during the RFA treatment.
Original languageEnglish
Title of host publicationProceedings Diffuse Optical Spectroscopy and Imaging VII
EditorsHamid Dehghani, Heidrun Wabnitz
Number of pages3
ISBN (Electronic)9781510628410
Publication statusPublished - 20 Jul 2019
EventEuropean Conferences on Biomedical Optics 2019 - ICM─International Congress Center, Munich, Germany
Duration: 23 Jun 201927 Jun 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceEuropean Conferences on Biomedical Optics 2019


  • Diffuse optical spectroscopy
  • absorption
  • light scattering
  • liver
  • monitoring
  • non-invasive
  • radio frequency ablation


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