Motor cortex stimulation: role of computer modeling

L. Manola, J. Holsheimer

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

    9 Citations (Scopus)


    Motor cortex stimulation (MCS) is a promising clinical technique used to treat chronic, otherwise intractable pain. However, the mechanisms by which the neural elements that are stimulated during MCS induce pain relief are not understood. Neither is it known which neural elements (fibers (parallel or perpendicular to the cortical layers, below or away from the electrode), cell bodies or dendrites) are immediately excited by the electrical pulses in MCS. The therapy and its efficacy are less likely to be improved until it is better understood how it may work. In this chapter we present our efforts to resolve this issue. Our computer model of MCS is introduced and some of its predictions are discussed. In particular, the influence of stimulus polarity and electrode position on the electrical field and excitation thresholds of different neural elements is addressed. Such predictions, supported with clinical evidence, should help to elucidate the immediate effects of an electrical stimulus applied over the motor cortex and may ultimately lead to optimizations of the therapy.
    Original languageUndefined
    Title of host publicationOperative neuromodulation, vol. 2: neural networks surgery
    EditorsD.E. Sakas, B.A Simpson
    Place of PublicationWien
    Number of pages10
    ISBN (Print)3-211-33080-1
    Publication statusPublished - Jun 2007

    Publication series

    NameActa Neurochir Suppl
    PublisherSpringer Verlag


    • Cathode
    • Chronic pain
    • Neuromodulation
    • Motor cortex stimulation
    • Computer modeling
    • IR-63696
    • neurostimulation
    • EWI-8173
    • BSS-Biomechatronics and rehabilitation technology
    • METIS-241690
    • Anode

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