Multi-color stimulated Raman scattering with a frame-to-frame wavelength-tunable fiber-based light source

T Würthwein; K. Wallmeier; M. Brinkmann; T Hellwig; N.M. Lüpken; N.S. Lemberger; C Fallnich

doi:10.1364/BOE.436299

Multi-color stimulated Raman scattering with a frame-to-frame wavelength-tunable fiber-based light source

T Würthwein^*
, K. Wallmeier
, M. Brinkmann
, T Hellwig
, N.M. Lüpken
, N.S. Lemberger
, C Fallnich

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

83 Downloads (Pure)

Abstract

We present multi-color imaging by stimulated Raman scattering (SRS) enabled by an ultrafast fiber-based light source with integrated amplitude modulation and frame-to-frame wavelength tuning. With a relative intensity noise level of -153.7 dBc/Hz at 20.25MHz the light source is well suited for SRS imaging and outperforms other fiber-based light source concepts for SRS imaging. The light source is tunable in under 5 ms per arbitrary wavelength step between 700 cm-1 and 3200 cm-1, which allows for addressing Raman resonances from the fingerprint to the CH-stretch region. Moreover, the compact and environmentally stable system is predestined for fast multi-color assessments of medical or rapidly evolving samples with high chemical specificity, paving the way for diagnostics and sensing outside of specialized laser laboratories.

Original language	English
Pages (from-to)	6228-6236
Number of pages	9
Journal	Biomedical optics express
Volume	12
Issue number	10
DOIs	https://doi.org/10.1364/BOE.436299
Publication status	Published - 1 Oct 2021

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boe-12-10-6228Final published version, 3.2 MBLicence: CC BY

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title = "Multi-color stimulated Raman scattering with a frame-to-frame wavelength-tunable fiber-based light source",

abstract = "We present multi-color imaging by stimulated Raman scattering (SRS) enabled by an ultrafast fiber-based light source with integrated amplitude modulation and frame-to-frame wavelength tuning. With a relative intensity noise level of -153.7 dBc/Hz at 20.25MHz the light source is well suited for SRS imaging and outperforms other fiber-based light source concepts for SRS imaging. The light source is tunable in under 5 ms per arbitrary wavelength step between 700 cm-1 and 3200 cm-1, which allows for addressing Raman resonances from the fingerprint to the CH-stretch region. Moreover, the compact and environmentally stable system is predestined for fast multi-color assessments of medical or rapidly evolving samples with high chemical specificity, paving the way for diagnostics and sensing outside of specialized laser laboratories.",

author = "T W{\"u}rthwein and K. Wallmeier and M. Brinkmann and T Hellwig and N.M. L{\"u}pken and N.S. Lemberger and C Fallnich",

note = "Funding Information: Acknowledgments. The authors gratefully thank Ingo Diedrich for his strong support in the fabrication of the detector used for the SRS measurements. We acknowledge support from the Open Access Publication Fund of the University of Muenster. Publisher Copyright: {\textcopyright} 2021 OSA - The Optical Society. All rights reserved.",

year = "2021",

month = oct,

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doi = "10.1364/BOE.436299",

language = "English",

volume = "12",

pages = "6228--6236",

journal = "Biomedical optics express",

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TY - JOUR

T1 - Multi-color stimulated Raman scattering with a frame-to-frame wavelength-tunable fiber-based light source

AU - Würthwein, T

AU - Wallmeier, K.

AU - Brinkmann, M.

AU - Hellwig, T

AU - Lüpken, N.M.

AU - Lemberger, N.S.

AU - Fallnich, C

N1 - Funding Information: Acknowledgments. The authors gratefully thank Ingo Diedrich for his strong support in the fabrication of the detector used for the SRS measurements. We acknowledge support from the Open Access Publication Fund of the University of Muenster. Publisher Copyright: © 2021 OSA - The Optical Society. All rights reserved.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - We present multi-color imaging by stimulated Raman scattering (SRS) enabled by an ultrafast fiber-based light source with integrated amplitude modulation and frame-to-frame wavelength tuning. With a relative intensity noise level of -153.7 dBc/Hz at 20.25MHz the light source is well suited for SRS imaging and outperforms other fiber-based light source concepts for SRS imaging. The light source is tunable in under 5 ms per arbitrary wavelength step between 700 cm-1 and 3200 cm-1, which allows for addressing Raman resonances from the fingerprint to the CH-stretch region. Moreover, the compact and environmentally stable system is predestined for fast multi-color assessments of medical or rapidly evolving samples with high chemical specificity, paving the way for diagnostics and sensing outside of specialized laser laboratories.

AB - We present multi-color imaging by stimulated Raman scattering (SRS) enabled by an ultrafast fiber-based light source with integrated amplitude modulation and frame-to-frame wavelength tuning. With a relative intensity noise level of -153.7 dBc/Hz at 20.25MHz the light source is well suited for SRS imaging and outperforms other fiber-based light source concepts for SRS imaging. The light source is tunable in under 5 ms per arbitrary wavelength step between 700 cm-1 and 3200 cm-1, which allows for addressing Raman resonances from the fingerprint to the CH-stretch region. Moreover, the compact and environmentally stable system is predestined for fast multi-color assessments of medical or rapidly evolving samples with high chemical specificity, paving the way for diagnostics and sensing outside of specialized laser laboratories.

UR - https://www.scopus.com/pages/publications/85115101268

U2 - 10.1364/BOE.436299

DO - 10.1364/BOE.436299

M3 - Article

AN - SCOPUS:85115101268

SN - 2156-7085

VL - 12

SP - 6228

EP - 6236

JO - Biomedical optics express

JF - Biomedical optics express

IS - 10

ER -

Multi-color stimulated Raman scattering with a frame-to-frame wavelength-tunable fiber-based light source

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