TY - JOUR
T1 - Multicenter cohort study on treatment results and risk factors in stage II endometrial carcinoma
AU - Jobsen, J.J.
AU - Lybeert, M.L.M.
AU - van der Steen-Banasik, E.M.
AU - Slot, A.
AU - van der Palen, J.
AU - ten Cate, L.N.
AU - Scholten, A.
AU - Coen, V.
AU - Schutter, E.M.
AU - Siesling, S.
PY - 2008
Y1 - 2008
N2 - The aim of this study was to report outcome data and prognostic factors from a large cohort of pathologic stage II endometrioid type endometrial carcinoma. One hundred forty-two stage IIA–B patients were included. A central histopathologic review was performed. Follow-up ranged from 2 to 217 months with a median of 61 months. End points of the study were local and locoregional recurrence rates, distant metastasis–free survival (DMFS), disease-free survival (DFS), and disease-specific survival (DSS). The local failure rate was 5.1% for stage IIA patients and 10.8% for stage IIB patients. Grade was the only significant prognostic factor for local failure. With respect to DMFS, DFS, and DSS, grade 3 showed to be the most prominent prognostic factor in multivariate analyses. Lymphvascular space involvement combined with grades 3 and 2 and myometrial invasion greater than 0.5 also showed to be significant for DMFS and DFS. Our study showed grade 3 to be the most important single independent predictive factor for locoregional and distant recurrences in endometrial carcinoma stage II
AB - The aim of this study was to report outcome data and prognostic factors from a large cohort of pathologic stage II endometrioid type endometrial carcinoma. One hundred forty-two stage IIA–B patients were included. A central histopathologic review was performed. Follow-up ranged from 2 to 217 months with a median of 61 months. End points of the study were local and locoregional recurrence rates, distant metastasis–free survival (DMFS), disease-free survival (DFS), and disease-specific survival (DSS). The local failure rate was 5.1% for stage IIA patients and 10.8% for stage IIB patients. Grade was the only significant prognostic factor for local failure. With respect to DMFS, DFS, and DSS, grade 3 showed to be the most prominent prognostic factor in multivariate analyses. Lymphvascular space involvement combined with grades 3 and 2 and myometrial invasion greater than 0.5 also showed to be significant for DMFS and DFS. Our study showed grade 3 to be the most important single independent predictive factor for locoregional and distant recurrences in endometrial carcinoma stage II
KW - n/a OA procedure
U2 - 10.1111/j.1525-1438.2007.01142.x
DO - 10.1111/j.1525-1438.2007.01142.x
M3 - Article
SN - 1048-891X
VL - 18
SP - 1071
EP - 1078
JO - International journal of gynecological cancer
JF - International journal of gynecological cancer
IS - 5
ER -
