Multicenter cohort study on treatment results and risk factors in stage II endometrial carcinoma

J.J. Jobsen, M.L.M. Lybeert, E.M. van der Steen-Banasik, A. Slot, J. van der Palen, L.N. ten Cate, A. Scholten, V. Coen, E.M. Schutter, S. Siesling

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The aim of this study was to report outcome data and prognostic factors from a large cohort of pathologic stage II endometrioid type endometrial carcinoma. One hundred forty-two stage IIA–B patients were included. A central histopathologic review was performed. Follow-up ranged from 2 to 217 months with a median of 61 months. End points of the study were local and locoregional recurrence rates, distant metastasis–free survival (DMFS), disease-free survival (DFS), and disease-specific survival (DSS). The local failure rate was 5.1% for stage IIA patients and 10.8% for stage IIB patients. Grade was the only significant prognostic factor for local failure. With respect to DMFS, DFS, and DSS, grade 3 showed to be the most prominent prognostic factor in multivariate analyses. Lymphvascular space involvement combined with grades 3 and 2 and myometrial invasion greater than 0.5 also showed to be significant for DMFS and DFS. Our study showed grade 3 to be the most important single independent predictive factor for locoregional and distant recurrences in endometrial carcinoma stage II
Original languageEnglish
Pages (from-to)1071-1078
JournalInternational journal of gynecological cancer
Issue number5
Publication statusPublished - 2008


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