Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract

Markus Nordlund*, Miloslav Belka, A.K. Kuczaj, Frtantisek Lizal, Jan Jedelsky, Jakub Elcner, Miloslav Jicha, Youri Sauser, Soazig Le Bouhellec, Stephane Cosandey, Shoaib Majeed, Grégory Vuillaume, Manuel C. Peitsch, Julia Hoeng

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Inhalation of aerosols generated by electronic cigarettes leads to deposition of multiple chemical compounds in the human airways. In this work, an experimental method to determine regional deposition of multicomponent aerosols in an in vitro segmented, realistic human lung geometry was developed and applied to two aerosols, i.e. a monodisperse glycerol aerosol and a multicomponent aerosol. The method comprised the following steps: (1) lung cast model preparation, (2) aerosol generation and exposure, (3) extraction of deposited mass, (4) chemical quantification and (5) data processing. The method showed good agreement with literature data for the deposition efficiency when using a monodisperse glycerol aerosol, with a mass median aerodynamic diameter (MMAD) of 2.3 μm and a constant flow rate of 15 L/min. The highest deposition surface density rate was observed in the bifurcation segments, indicating inertial impaction deposition. The experimental method was also applied to the deposition of a nebulized multicomponent aerosol with a MMAD of 0.50 μm and a constant flow rate of 15 L/min. The deposited amounts of glycerol, propylene glycol and nicotine were quantified. The three analyzed compounds showed similar deposition patterns and fractions as for the monodisperse glycerol aerosol, indicating that the compounds most likely deposited as parts of the same droplets. The developed method can be used to determine regional deposition for multicomponent aerosols, provided that the compounds are of low volatility. The generated data can be used to validate aerosol deposition simulations and to gain insight in deposition of electronic cigarette aerosols in human airways.
    Original languageEnglish
    Pages (from-to)113-125
    JournalInhalation Toxicology
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Aerosol particle deposition
    • Regional deposition
    • Lung cast
    • Respiratory tract
    • Monodisperse glycerol aerosol
    • Multicomponent aerosol
    • Gas chromatography-mass spectrometry

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