TY - JOUR
T1 - Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract
AU - Nordlund, Markus
AU - Belka, Miloslav
AU - Kuczaj, A.K.
AU - Lizal, Frtantisek
AU - Jedelsky, Jan
AU - Elcner, Jakub
AU - Jicha, Miloslav
AU - Sauser, Youri
AU - Le Bouhellec, Soazig
AU - Cosandey, Stephane
AU - Majeed, Shoaib
AU - Vuillaume, Grégory
AU - Peitsch, Manuel C.
AU - Hoeng, Julia
PY - 2017
Y1 - 2017
N2 - Inhalation of aerosols generated by electronic cigarettes leads to deposition of multiple chemical compounds in the human airways. In this work, an experimental method to determine regional deposition of multicomponent aerosols in an in vitro segmented, realistic human lung geometry was developed and applied to two aerosols, i.e. a monodisperse glycerol aerosol and a multicomponent aerosol. The method comprised the following steps: (1) lung cast model preparation, (2) aerosol generation and exposure, (3) extraction of deposited mass, (4) chemical quantification and (5) data processing. The method showed good agreement with literature data for the deposition efficiency when using a monodisperse glycerol aerosol, with a mass median aerodynamic diameter (MMAD) of 2.3 μm and a constant flow rate of 15 L/min. The highest deposition surface density rate was observed in the bifurcation segments, indicating inertial impaction deposition. The experimental method was also applied to the deposition of a nebulized multicomponent aerosol with a MMAD of 0.50 μm and a constant flow rate of 15 L/min. The deposited amounts of glycerol, propylene glycol and nicotine were quantified. The three analyzed compounds showed similar deposition patterns and fractions as for the monodisperse glycerol aerosol, indicating that the compounds most likely deposited as parts of the same droplets. The developed method can be used to determine regional deposition for multicomponent aerosols, provided that the compounds are of low volatility. The generated data can be used to validate aerosol deposition simulations and to gain insight in deposition of electronic cigarette aerosols in human airways.
AB - Inhalation of aerosols generated by electronic cigarettes leads to deposition of multiple chemical compounds in the human airways. In this work, an experimental method to determine regional deposition of multicomponent aerosols in an in vitro segmented, realistic human lung geometry was developed and applied to two aerosols, i.e. a monodisperse glycerol aerosol and a multicomponent aerosol. The method comprised the following steps: (1) lung cast model preparation, (2) aerosol generation and exposure, (3) extraction of deposited mass, (4) chemical quantification and (5) data processing. The method showed good agreement with literature data for the deposition efficiency when using a monodisperse glycerol aerosol, with a mass median aerodynamic diameter (MMAD) of 2.3 μm and a constant flow rate of 15 L/min. The highest deposition surface density rate was observed in the bifurcation segments, indicating inertial impaction deposition. The experimental method was also applied to the deposition of a nebulized multicomponent aerosol with a MMAD of 0.50 μm and a constant flow rate of 15 L/min. The deposited amounts of glycerol, propylene glycol and nicotine were quantified. The three analyzed compounds showed similar deposition patterns and fractions as for the monodisperse glycerol aerosol, indicating that the compounds most likely deposited as parts of the same droplets. The developed method can be used to determine regional deposition for multicomponent aerosols, provided that the compounds are of low volatility. The generated data can be used to validate aerosol deposition simulations and to gain insight in deposition of electronic cigarette aerosols in human airways.
KW - Aerosol particle deposition
KW - Regional deposition
KW - Lung cast
KW - Respiratory tract
KW - Monodisperse glycerol aerosol
KW - Multicomponent aerosol
KW - Gas chromatography-mass spectrometry
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85018751806&partnerID=MN8TOARS
U2 - 10.1080/08958378.2017.1315196
DO - 10.1080/08958378.2017.1315196
M3 - Article
VL - 29
SP - 113
EP - 125
JO - Inhalation Toxicology
JF - Inhalation Toxicology
SN - 0895-8378
IS - 3
ER -