Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing

Yunlong Yu, Pengfei Li, Chenglei Zhu, Ning Ning, Shiyong Zhang, G. Julius Vancso

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A growth in the use of antibiotics and the related evolution of patients' drug resistance calls for an urgent response for the development of novel curing approaches without using synthetic antibiotics. Here, the fabrication of a low-cost cryogel for wound dressing applications is demonstrated. The cryogel is composed of only naturally derived components, including chitosan/silk fibroin as the scaffold and tannic acid/ferric ion (TA/Fe3+) as the stimuli-responsive agent for photothermal therapy. Based on the multiple weak hydrogen bonds and metal ligand coordination, the cryogel exhibits good flexibility and recoverability. Its highly porous structure renders the cryogel to be strongly hygroscopic to absorb blood for hemostasis. The cryogel exhibits excellent antibacterial activity to both Gram-negative and positive bacteria, benefiting from the high photothermal transition activity of the TA/Fe3+ complex. Furthermore, the cryogel can efficiently promote cell proliferation in vitro. Significantly, animal experiments also reveal that the cryogel effectively eradicate microbes at the wound and accelerate the wound healing process. In summary, this novel biorenewable cryogel demonstrates excellent hygroscopic and hemostatic performance, photothermal antimicrobial activity, and accelerates skin regeneration, which has great application potential as a promising wound dressing material in the clinical use.

Original languageEnglish
Article number1904402
JournalAdvanced functional materials
Volume29
Issue number35
Early online date15 Jul 2019
DOIs
Publication statusPublished - 28 Aug 2019

Fingerprint

Cryogels
wound healing
Antibiotics
hemostatics
platforms
antibiotics
Cell proliferation
Silk
recoverability
Chitosan
Scaffolds
ferric ions
Curing
silk
Bacteria
Skin
Hydrogen bonds
Animals
Blood
Ligands

Keywords

  • UT-Hybrid-D
  • hemostasis
  • photothermal therapy
  • tannic acid
  • wound dressing
  • chitosan

Cite this

Yu, Yunlong ; Li, Pengfei ; Zhu, Chenglei ; Ning, Ning ; Zhang, Shiyong ; Vancso, G. Julius. / Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing. In: Advanced functional materials. 2019 ; Vol. 29, No. 35.
@article{85c33b0ffabf46109eec6bdeb64cca0e,
title = "Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing",
abstract = "A growth in the use of antibiotics and the related evolution of patients' drug resistance calls for an urgent response for the development of novel curing approaches without using synthetic antibiotics. Here, the fabrication of a low-cost cryogel for wound dressing applications is demonstrated. The cryogel is composed of only naturally derived components, including chitosan/silk fibroin as the scaffold and tannic acid/ferric ion (TA/Fe3+) as the stimuli-responsive agent for photothermal therapy. Based on the multiple weak hydrogen bonds and metal ligand coordination, the cryogel exhibits good flexibility and recoverability. Its highly porous structure renders the cryogel to be strongly hygroscopic to absorb blood for hemostasis. The cryogel exhibits excellent antibacterial activity to both Gram-negative and positive bacteria, benefiting from the high photothermal transition activity of the TA/Fe3+ complex. Furthermore, the cryogel can efficiently promote cell proliferation in vitro. Significantly, animal experiments also reveal that the cryogel effectively eradicate microbes at the wound and accelerate the wound healing process. In summary, this novel biorenewable cryogel demonstrates excellent hygroscopic and hemostatic performance, photothermal antimicrobial activity, and accelerates skin regeneration, which has great application potential as a promising wound dressing material in the clinical use.",
keywords = "UT-Hybrid-D, hemostasis, photothermal therapy, tannic acid, wound dressing, chitosan",
author = "Yunlong Yu and Pengfei Li and Chenglei Zhu and Ning Ning and Shiyong Zhang and Vancso, {G. Julius}",
note = "Wiley deal",
year = "2019",
month = "8",
day = "28",
doi = "10.1002/adfm.201904402",
language = "English",
volume = "29",
journal = "Advanced functional materials",
issn = "1616-301X",
publisher = "Wiley-VCH Verlag",
number = "35",

}

Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing. / Yu, Yunlong; Li, Pengfei; Zhu, Chenglei; Ning, Ning; Zhang, Shiyong; Vancso, G. Julius.

In: Advanced functional materials, Vol. 29, No. 35, 1904402, 28.08.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing

AU - Yu, Yunlong

AU - Li, Pengfei

AU - Zhu, Chenglei

AU - Ning, Ning

AU - Zhang, Shiyong

AU - Vancso, G. Julius

N1 - Wiley deal

PY - 2019/8/28

Y1 - 2019/8/28

N2 - A growth in the use of antibiotics and the related evolution of patients' drug resistance calls for an urgent response for the development of novel curing approaches without using synthetic antibiotics. Here, the fabrication of a low-cost cryogel for wound dressing applications is demonstrated. The cryogel is composed of only naturally derived components, including chitosan/silk fibroin as the scaffold and tannic acid/ferric ion (TA/Fe3+) as the stimuli-responsive agent for photothermal therapy. Based on the multiple weak hydrogen bonds and metal ligand coordination, the cryogel exhibits good flexibility and recoverability. Its highly porous structure renders the cryogel to be strongly hygroscopic to absorb blood for hemostasis. The cryogel exhibits excellent antibacterial activity to both Gram-negative and positive bacteria, benefiting from the high photothermal transition activity of the TA/Fe3+ complex. Furthermore, the cryogel can efficiently promote cell proliferation in vitro. Significantly, animal experiments also reveal that the cryogel effectively eradicate microbes at the wound and accelerate the wound healing process. In summary, this novel biorenewable cryogel demonstrates excellent hygroscopic and hemostatic performance, photothermal antimicrobial activity, and accelerates skin regeneration, which has great application potential as a promising wound dressing material in the clinical use.

AB - A growth in the use of antibiotics and the related evolution of patients' drug resistance calls for an urgent response for the development of novel curing approaches without using synthetic antibiotics. Here, the fabrication of a low-cost cryogel for wound dressing applications is demonstrated. The cryogel is composed of only naturally derived components, including chitosan/silk fibroin as the scaffold and tannic acid/ferric ion (TA/Fe3+) as the stimuli-responsive agent for photothermal therapy. Based on the multiple weak hydrogen bonds and metal ligand coordination, the cryogel exhibits good flexibility and recoverability. Its highly porous structure renders the cryogel to be strongly hygroscopic to absorb blood for hemostasis. The cryogel exhibits excellent antibacterial activity to both Gram-negative and positive bacteria, benefiting from the high photothermal transition activity of the TA/Fe3+ complex. Furthermore, the cryogel can efficiently promote cell proliferation in vitro. Significantly, animal experiments also reveal that the cryogel effectively eradicate microbes at the wound and accelerate the wound healing process. In summary, this novel biorenewable cryogel demonstrates excellent hygroscopic and hemostatic performance, photothermal antimicrobial activity, and accelerates skin regeneration, which has great application potential as a promising wound dressing material in the clinical use.

KW - UT-Hybrid-D

KW - hemostasis

KW - photothermal therapy

KW - tannic acid

KW - wound dressing

KW - chitosan

UR - http://www.scopus.com/inward/record.url?scp=85069911331&partnerID=8YFLogxK

U2 - 10.1002/adfm.201904402

DO - 10.1002/adfm.201904402

M3 - Article

VL - 29

JO - Advanced functional materials

JF - Advanced functional materials

SN - 1616-301X

IS - 35

M1 - 1904402

ER -