Multifunctional poly(ethylene glycol)s

Boris Obermeier, Frederik Wurm, Christine Mangold, Holger Frey*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

142 Citations (Scopus)

Abstract

In the rapidly evolving multidisciplinary field of polymer therapeutics, tailored polymer structures represent the key constituent to explore and harvest the potential of bioactive macromolecular hybrid structures. In light of the recent developments for anticancer drug conjugates, multifunctional polymers are becoming ever more relevant as drug carriers. However, the potentially best suited polymer, poly(ethylene glycol) (PEG), is unfavorable owing to its limited functionality. Therefore, multifunctional linear copolymers (mf-PEGs) based on ethylene oxide (EO) and appropriate epoxide comonomers are attracting increased attention. Precisely engineered via living anionic polymerization and defined with state-of-the-art characterization techniques-for example real-time 1H NMR spectroscopy monitoring of the EO polymerization kinetics-this emerging class of polymers embodies a powerful platform for bio- and drug conjugation.

Original languageEnglish
Pages (from-to)7988-7997
Number of pages10
JournalAngewandte Chemie - International Edition
Volume50
Issue number35
DOIs
Publication statusPublished - 22 Aug 2011
Externally publishedYes

Keywords

  • bioconjugates
  • epoxides
  • multivalency
  • poly(ethylene glycol)
  • polyethers

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