TY - JOUR
T1 - Multimodal [GdO]+[ICG]− Nanoparticles for Optical, Photoacoustic, and Magnetic Resonance Imaging
AU - Poß, Marieke
AU - Tower, Robert J.
AU - Napp, Joanna
AU - Appold, Lia Christina
AU - Lammers, Twan
AU - Alves, Frauke
AU - Glüer, Claus Christian
AU - Boretius, Susann
AU - Feldmann, Claus
PY - 2017/4/25
Y1 - 2017/4/25
N2 - Multimodal contrast agents with high biocompatibility and biodegradability, as well as low material complexity, are in great demand for clinical diagnostics at different scales of resolution and/or for translating preclinical diagnosis into intraoperative imaging. Multimodality, however, often results in multicomponent and multistructured materials with complexity becoming a severe restriction for synthesis, approval, and use in routine clinical practice. Here, we present sulfonate-based saline [GdO]+[ICG]− (ICG, indocyanine green) inorganic-organic hybrid nanoparticles (IOH-NPs with an inorganic [GdO]+ cation and an organic [ICG]− anion) as a novel, multimodality contrast agent for optical, photoacoustic, and magnetic resonance imaging (OI, PAI, MRI). [GdO]+[ICG]− IOH-NPs have a plain composition based on clinically used constituents and are prepared as an insoluble saline compound in water. The high [ICG]− content (81 wt %) ensures intense near-infrared emission (780-840 nm) and a strong photoacoustic signal. First, in vitro studies demonstrate longer detectability and greater emission intensity for [GdO]+[ICG]− IOH-NP suspensions than for ICG solutions, as well as a reduced toxicity compared to that of Gd-DTPA, a standard MRI contrast agent. Conceptual in vivo studies confirm the utility of the [GdO]+[ICG]− IOH-NPs for optical and magnetic resonance imaging with a T1 relaxivity better than that of Gd-DTPA. Taken together, [GdO]+[ICG]− represents a new compound and nanomaterial that can be highly interesting as a multimodal contrast agent.
AB - Multimodal contrast agents with high biocompatibility and biodegradability, as well as low material complexity, are in great demand for clinical diagnostics at different scales of resolution and/or for translating preclinical diagnosis into intraoperative imaging. Multimodality, however, often results in multicomponent and multistructured materials with complexity becoming a severe restriction for synthesis, approval, and use in routine clinical practice. Here, we present sulfonate-based saline [GdO]+[ICG]− (ICG, indocyanine green) inorganic-organic hybrid nanoparticles (IOH-NPs with an inorganic [GdO]+ cation and an organic [ICG]− anion) as a novel, multimodality contrast agent for optical, photoacoustic, and magnetic resonance imaging (OI, PAI, MRI). [GdO]+[ICG]− IOH-NPs have a plain composition based on clinically used constituents and are prepared as an insoluble saline compound in water. The high [ICG]− content (81 wt %) ensures intense near-infrared emission (780-840 nm) and a strong photoacoustic signal. First, in vitro studies demonstrate longer detectability and greater emission intensity for [GdO]+[ICG]− IOH-NP suspensions than for ICG solutions, as well as a reduced toxicity compared to that of Gd-DTPA, a standard MRI contrast agent. Conceptual in vivo studies confirm the utility of the [GdO]+[ICG]− IOH-NPs for optical and magnetic resonance imaging with a T1 relaxivity better than that of Gd-DTPA. Taken together, [GdO]+[ICG]− represents a new compound and nanomaterial that can be highly interesting as a multimodal contrast agent.
UR - http://www.scopus.com/inward/record.url?scp=85018642409&partnerID=8YFLogxK
U2 - 10.1021/acs.chemmater.6b05406
DO - 10.1021/acs.chemmater.6b05406
M3 - Article
AN - SCOPUS:85018642409
VL - 29
SP - 3547
EP - 3554
JO - Chemistry of materials
JF - Chemistry of materials
SN - 0897-4756
IS - 8
ER -