Multimodal [GdO]+[ICG] Nanoparticles for Optical, Photoacoustic, and Magnetic Resonance Imaging

Marieke Poß, Robert J. Tower, Joanna Napp, Lia Christina Appold, Twan Lammers, Frauke Alves, Claus Christian Glüer, Susann Boretius, Claus Feldmann*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)
2 Downloads (Pure)

Abstract

Multimodal contrast agents with high biocompatibility and biodegradability, as well as low material complexity, are in great demand for clinical diagnostics at different scales of resolution and/or for translating preclinical diagnosis into intraoperative imaging. Multimodality, however, often results in multicomponent and multistructured materials with complexity becoming a severe restriction for synthesis, approval, and use in routine clinical practice. Here, we present sulfonate-based saline [GdO]+[ICG] (ICG, indocyanine green) inorganic-organic hybrid nanoparticles (IOH-NPs with an inorganic [GdO]+ cation and an organic [ICG] anion) as a novel, multimodality contrast agent for optical, photoacoustic, and magnetic resonance imaging (OI, PAI, MRI). [GdO]+[ICG] IOH-NPs have a plain composition based on clinically used constituents and are prepared as an insoluble saline compound in water. The high [ICG] content (81 wt %) ensures intense near-infrared emission (780-840 nm) and a strong photoacoustic signal. First, in vitro studies demonstrate longer detectability and greater emission intensity for [GdO]+[ICG] IOH-NP suspensions than for ICG solutions, as well as a reduced toxicity compared to that of Gd-DTPA, a standard MRI contrast agent. Conceptual in vivo studies confirm the utility of the [GdO]+[ICG] IOH-NPs for optical and magnetic resonance imaging with a T1 relaxivity better than that of Gd-DTPA. Taken together, [GdO]+[ICG] represents a new compound and nanomaterial that can be highly interesting as a multimodal contrast agent.

Original languageEnglish
Pages (from-to)3547-3554
Number of pages8
JournalChemistry of materials
Volume29
Issue number8
DOIs
Publication statusPublished - 25 Apr 2017

Keywords

  • n/a OA procedure

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