Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

Nathalie Picollet-D'hahan*, Agnieszka Zuchowska, Iris Lemeunier, Séverine Le Gac

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

71 Citations (Scopus)
43 Downloads (Pure)


Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which human health research is conducted. After briefly reviewing the need for comprehensive multiorgan models with a systemic dimension, we highlight scenarios in which multiorgan models are advantageous. We next overview existing multi-OoC platforms, including integrated body-on-a-chip devices and modular approaches involving interconnected organ-specific modules. We highlight how multi-OoC models can provide unique information that is not accessible using single-OoC models. Finally, we discuss remaining challenges for the realization of multi-OoC platforms and their worldwide adoption. We anticipate that multi-OoC technology will metamorphose research in biology and medicine by providing holistic and personalized models for understanding and treating multisystem diseases.

Original languageEnglish
Pages (from-to)788-810
Number of pages23
JournalTrends in biotechnology
Issue number8
Publication statusPublished - Aug 2021


  • Cross-organ vascularization
  • Microfluidics
  • Organ-on-a-chip
  • Physiological barriers
  • Systemic diseases
  • UT-Hybrid-D


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