TY - JOUR
T1 - Multiorgan-on-a-Chip
T2 - A Systemic Approach To Model and Decipher Inter-Organ Communication
AU - Picollet-D'hahan, Nathalie
AU - Zuchowska, Agnieszka
AU - Lemeunier, Iris
AU - Le Gac, Séverine
N1 - Funding Information:
A.Z. and S.L.G. acknowledge financial support from the CHIP-ME project (Cross-organ Human In Vitro Platforms for Metastatic Environments) funded by Health Holland (project TKI-LSH LSHM19012 ). N.P.D and I.L. acknowledge financial support from the CEA PhD program. Figures 1 and 3 , and Figure I in Box 1 , contain elements from SMART Servier Medical Art by Servier licensed under a Creative Commons Attribution 3.0 Unported License.
Publisher Copyright:
© 2020 The Authors
PY - 2021/8
Y1 - 2021/8
N2 - Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which human health research is conducted. After briefly reviewing the need for comprehensive multiorgan models with a systemic dimension, we highlight scenarios in which multiorgan models are advantageous. We next overview existing multi-OoC platforms, including integrated body-on-a-chip devices and modular approaches involving interconnected organ-specific modules. We highlight how multi-OoC models can provide unique information that is not accessible using single-OoC models. Finally, we discuss remaining challenges for the realization of multi-OoC platforms and their worldwide adoption. We anticipate that multi-OoC technology will metamorphose research in biology and medicine by providing holistic and personalized models for understanding and treating multisystem diseases.
AB - Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which human health research is conducted. After briefly reviewing the need for comprehensive multiorgan models with a systemic dimension, we highlight scenarios in which multiorgan models are advantageous. We next overview existing multi-OoC platforms, including integrated body-on-a-chip devices and modular approaches involving interconnected organ-specific modules. We highlight how multi-OoC models can provide unique information that is not accessible using single-OoC models. Finally, we discuss remaining challenges for the realization of multi-OoC platforms and their worldwide adoption. We anticipate that multi-OoC technology will metamorphose research in biology and medicine by providing holistic and personalized models for understanding and treating multisystem diseases.
KW - Cross-organ vascularization
KW - Microfluidics
KW - Organ-on-a-chip
KW - Physiological barriers
KW - Systemic diseases
KW - UT-Hybrid-D
UR - http://www.scopus.com/inward/record.url?scp=85100421002&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2020.11.014
DO - 10.1016/j.tibtech.2020.11.014
M3 - Review article
C2 - 33541718
AN - SCOPUS:85100421002
SN - 0167-7799
VL - 39
SP - 788
EP - 810
JO - Trends in biotechnology
JF - Trends in biotechnology
IS - 8
ER -