Multiple choice: leveraging instructive culture models to improve cartilage tissue engineering

Nicole Georgi

Research output: ThesisPhD Thesis - Research UT, graduation UT

40 Downloads (Pure)

Abstract

In the recent years, multipotent cells, like mesenchymal stromal/stem cells (MSCs), gained considerable interest in cell based cartilage tissue engineering strategies. MSCs abilities to differentiate into chondrocytes as well as to act as trophic mediators makes them a promising cell source for the use in cartilage repair. In general, this thesis addresses three major aspects for the use of MSCs in cartilage tissue engineering: I) the role of low oxygen tension to improve MSC performance during cellular expansion II) the role of low oxygen tension to alter chondrogenic differentiation quantity and quality and III) revealing MSCs role in co-culture approaches with human chondrocytes.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • van Blitterswijk, Clemens, Supervisor
  • Karperien, H.B.J., Advisor
Award date22 Mar 2013
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-3520-5
DOIs
Publication statusPublished - 22 Mar 2013

Keywords

  • IR-85221
  • METIS-295329

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