Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

    Research output: Contribution to journalMeeting AbstractAcademic

    Abstract

    Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.
    Original languageEnglish
    Article number632A
    Number of pages1
    JournalBiophysical journal
    Volume106
    Issue number2, Suppl. 1
    DOIs
    Publication statusPublished - 28 Jan 2014
    Event58th Annual Biophysical Society Meeting 2014 - San Francisco, United States
    Duration: 15 Feb 201419 Feb 2014
    Conference number: 58

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    Lab-On-A-Chip Devices
    Lipid Bilayers
    Membrane Lipids
    Ion Channels
    Preclinical Drug Evaluations
    Microfluidics

    Cite this

    @article{d2ad5a3a5ec2467ca95ded1778857ab2,
    title = "Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers",
    abstract = "Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.",
    author = "Alexander Prokofyev and Verena Stimberg and Johan Bomer and {de Boer}, Hans and {van den Berg}, Albert and {le Gac}, Severine",
    year = "2014",
    month = "1",
    day = "28",
    doi = "10.1016/j.bpj.2013.11.3496",
    language = "English",
    volume = "106",
    journal = "Biophysical journal",
    issn = "0006-3495",
    publisher = "Biophysical Society",
    number = "2, Suppl. 1",

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    Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers. / Prokofyev, Alexander; Stimberg, Verena; Bomer, Johan; de Boer, Hans; van den Berg, Albert; le Gac, Severine.

    In: Biophysical journal, Vol. 106, No. 2, Suppl. 1, 632A, 28.01.2014.

    Research output: Contribution to journalMeeting AbstractAcademic

    TY - JOUR

    T1 - Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

    AU - Prokofyev, Alexander

    AU - Stimberg, Verena

    AU - Bomer, Johan

    AU - de Boer, Hans

    AU - van den Berg, Albert

    AU - le Gac, Severine

    PY - 2014/1/28

    Y1 - 2014/1/28

    N2 - Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.

    AB - Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.

    U2 - 10.1016/j.bpj.2013.11.3496

    DO - 10.1016/j.bpj.2013.11.3496

    M3 - Meeting Abstract

    VL - 106

    JO - Biophysical journal

    JF - Biophysical journal

    SN - 0006-3495

    IS - 2, Suppl. 1

    M1 - 632A

    ER -