Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

Alexander Prokofyev, Verena Stimberg, Johan Bomer, Hans de Boer, Albert van den Berg, Severine le Gac

Research output: Contribution to journalMeeting AbstractAcademic

Abstract

Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.
Original languageEnglish
Article number632A
Number of pages1
JournalBiophysical journal
Volume106
Issue number2, Suppl. 1
DOIs
Publication statusPublished - 28 Jan 2014
Event58th Annual Biophysical Society Meeting 2014 - San Francisco, United States
Duration: 15 Feb 201419 Feb 2014
Conference number: 58

Fingerprint

Lab-On-A-Chip Devices
Lipid Bilayers
Membrane Lipids
Ion Channels
Preclinical Drug Evaluations
Microfluidics

Cite this

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title = "Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers",
abstract = "Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.",
author = "Alexander Prokofyev and Verena Stimberg and Johan Bomer and {de Boer}, Hans and {van den Berg}, Albert and {le Gac}, Severine",
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Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers. / Prokofyev, Alexander; Stimberg, Verena; Bomer, Johan; de Boer, Hans; van den Berg, Albert; le Gac, Severine.

In: Biophysical journal, Vol. 106, No. 2, Suppl. 1, 632A, 28.01.2014.

Research output: Contribution to journalMeeting AbstractAcademic

TY - JOUR

T1 - Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

AU - Prokofyev, Alexander

AU - Stimberg, Verena

AU - Bomer, Johan

AU - de Boer, Hans

AU - van den Berg, Albert

AU - le Gac, Severine

PY - 2014/1/28

Y1 - 2014/1/28

N2 - Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.

AB - Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.

U2 - 10.1016/j.bpj.2013.11.3496

DO - 10.1016/j.bpj.2013.11.3496

M3 - Meeting Abstract

VL - 106

JO - Biophysical journal

JF - Biophysical journal

SN - 0006-3495

IS - 2, Suppl. 1

M1 - 632A

ER -