Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

Alexander Prokofyev; Verena Stimberg; Johan Bomer; Hans de Boer; Albert van den Berg; Severine le Gac

doi:10.1016/j.bpj.2013.11.3496

Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

Alexander Prokofyev, Verena Stimberg, Johan Bomer, Hans de Boer, Albert van den Berg, Severine le Gac

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Abstract

Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.

Original language	English
Article number	632A
Number of pages	1
Journal	Biophysical journal
Volume	106
Issue number	2, Suppl. 1
DOIs	https://doi.org/10.1016/j.bpj.2013.11.3496
Publication status	Published - 28 Jan 2014
Event	58th Annual Biophysical Society Meeting 2014 - San Francisco, United States Duration: 15 Feb 2014 → 19 Feb 2014 Conference number: 58

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title = "Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers",

abstract = "Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.",

author = "Alexander Prokofyev and Verena Stimberg and Johan Bomer and {de Boer}, Hans and {van den Berg}, Albert and {le Gac}, Severine",

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T1 - Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

AU - Prokofyev, Alexander

AU - Stimberg, Verena

AU - Bomer, Johan

AU - de Boer, Hans

AU - van den Berg, Albert

AU - le Gac, Severine

N1 - Conference code: 58

PY - 2014/1/28

Y1 - 2014/1/28

N2 - Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.

AB - Bilayer lipid membranes (BLMs) are excellent platforms to study ion channels in a functional environment, and for drug screening assays. However, conventional electrophysiological BLM approaches do not meet the requirements for high throughput experiments due to the large volumes utilized, and the extensive manual procedures involved. In that context, microfluidics is a promising format to develop new platforms for high throughput electrophysiological measurements on ion channels incorporated in BLMs.

U2 - 10.1016/j.bpj.2013.11.3496

DO - 10.1016/j.bpj.2013.11.3496

M3 - Meeting Abstract

SN - 0006-3495

VL - 106

JO - Biophysical journal

JF - Biophysical journal

IS - 2, Suppl. 1

M1 - 632A

T2 - 58th Annual Biophysical Society Meeting 2014

Y2 - 15 February 2014 through 19 February 2014

ER -

Multiplexed microfluidic device for parallel electrophysiological measurements on independent planar lipid bilayers

Abstract

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