Multiplexed Organ-on-Chips with integrated macro valves for automated cell culture

Elsbeth G.B.M. Bossink, Anke Ricarda Vollertsen, Lieke P. Hagen , A. van der Meer, Loes Segerink, Mathieu Odijk

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

To translate Organ-on-Chips (OoCs) from academic proof-of-concept into commercially available systems, automation of fluid handling is essential. Integrated valves allow parallelization and automation, which are valuable tools for multiplex in vitro cell culture systems. Here, we show the fabrication of two devices, containing 8 culture chambers or 4 OoCs, each consisting of a top and a bottom channel. We show that all chambers and channels are individually addressable by actuation of the integrated pneumatic valves. An initial cell culture experiment shows that the device is suitable for cell culture.
Original languageEnglish
Title of host publication25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Pages1385-1386
Number of pages2
Publication statusPublished - 11 Oct 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 - Palm Springs, United States
Duration: 10 Oct 202114 Oct 2021
Conference number: 25
https://microtas2021.org/

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Abbreviated titleMicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs
Period10/10/2114/10/21
Internet address

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