Musculoskeletal Manifestations of COVID-19: A Systematic Search and Review

Moshiur Rahman Khasru; Abu Bakar Siddiq; Tangila Marzen; Mubdiur Rahman; Iffat Islam; Syed Ahmed Refaie; Tamjid Ali; Reaz Uddin; Mohammad Hasan; Radia Naz; Fariha Haseen; Syed Shariful Islam; Daniel Clegg; Johannes J. Rasker (Hans)

doi:10.22631/rr.2021.69997.1117

Musculoskeletal Manifestations of COVID-19: A Systematic Search and Review

Moshiur Rahman Khasru
, Abu Bakar Siddiq
, Tangila Marzen
, Mubdiur Rahman
, Iffat Islam
, Syed Ahmed Refaie
, Tamjid Ali
, Reaz Uddin
, Mohammad Hasan
, Radia Naz
, Fariha Haseen
, Syed Shariful Islam
, Daniel Clegg
, Johannes J. Rasker (Hans)^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

135 Downloads (Pure)

Abstract

Introduction: Coronavirus disease (COVID-19) started its journey from Wuhan, China and gradually became a pandemic. COVID-19 often affects the respiratory system, but symptoms may include fatigue, myalgia, arthralgia, arthritis, spine-, and bone pain as presenting complaints. In the present systematic search and review, we aim to highlight the musculoskeletal manifestations during COVID-19.

Methods: Using PubMed Central and Google Scholar search engines, we used as key words “muscle pain”, “joint pain”, “body ache”, “fatigue”, in Covid-19 patients. Results: After screening, a total of 76 articles were included following inclusion criteria dated between January 1 and July 1, 2020. All articles were published in English comprising 36558 COVID-19 cases. In cross sectional studies, fatigue was found in 55%, myalgia in 26%, and arthralgia in 20%, respectively. In cohort studies, fatigue was found in 35%, myalgia in 15%, and arthralgia in 5%, respectively. Sporadic case reports also mention back pain, bone pain, myositis and arthritis as presenting symptoms of COVID-19.

Discussion: Fatigue was the most frequent musculoskeletal (MSK) manifestion of COVID-19 followed by myalgia and joint pain. The frequency of the different MSK manifestations in COVID-19 may vary widely among different geographic regions.

Conclusions: MSK like fatigue, myalgia and arthralgia are frequent symptoms in COVID-19 patients and may vary in different countries.

Original language	English
Pages (from-to)	59-80
Journal	Rheumatology Research
Volume	6
Issue number	2
DOIs	https://doi.org/10.22631/rr.2021.69997.1117
Publication status	Published - 21 Apr 2021

Keywords

UT-Gold-D

Access to Document

10.22631/rr.2021.69997.1117Licence: CC BY

Khasru2021musculoskeletalFinal published version, 664 KBLicence: CC BY

Cite this

@article{fee1b109f5da44009a5e6146bdf4e3bc,

title = "Musculoskeletal Manifestations of COVID-19: A Systematic Search and Review",

abstract = "Introduction: Coronavirus disease (COVID-19) started its journey from Wuhan, China and gradually became a pandemic. COVID-19 often affects the respiratory system, but symptoms may include fatigue, myalgia, arthralgia, arthritis, spine-, and bone pain as presenting complaints. In the present systematic search and review, we aim to highlight the musculoskeletal manifestations during COVID-19. Methods: Using PubMed Central and Google Scholar search engines, we used as key words “muscle pain”, “joint pain”, “body ache”, “fatigue”, in Covid-19 patients. Results: After screening, a total of 76 articles were included following inclusion criteria dated between January 1 and July 1, 2020. All articles were published in English comprising 36558 COVID-19 cases. In cross sectional studies, fatigue was found in 55\%, myalgia in 26\%, and arthralgia in 20\%, respectively. In cohort studies, fatigue was found in 35\%, myalgia in 15\%, and arthralgia in 5\%, respectively. Sporadic case reports also mention back pain, bone pain, myositis and arthritis as presenting symptoms of COVID-19. Discussion: Fatigue was the most frequent musculoskeletal (MSK) manifestion of COVID-19 followed by myalgia and joint pain. The frequency of the different MSK manifestations in COVID-19 may vary widely among different geographic regions. Conclusions: MSK like fatigue, myalgia and arthralgia are frequent symptoms in COVID-19 patients and may vary in different countries.",

keywords = "UT-Gold-D",

author = "Khasru, \{Moshiur Rahman\} and Siddiq, \{Abu Bakar\} and Tangila Marzen and Mubdiur Rahman and Iffat Islam and Refaie, \{Syed Ahmed\} and Tamjid Ali and Reaz Uddin and Mohammad Hasan and Radia Naz and Fariha Haseen and Islam, \{Syed Shariful\} and Daniel Clegg and \{Rasker (Hans)\}, \{Johannes J.\}",

year = "2021",

month = apr,

day = "21",

doi = "10.22631/rr.2021.69997.1117",

language = "English",

volume = "6",

pages = "59--80",

journal = "Rheumatology Research",

issn = "2476-5856",

publisher = "Iranian Rheumatology Association",

number = "2",

}

TY - JOUR

T1 - Musculoskeletal Manifestations of COVID-19

T2 - A Systematic Search and Review

AU - Khasru, Moshiur Rahman

AU - Siddiq, Abu Bakar

AU - Marzen, Tangila

AU - Rahman, Mubdiur

AU - Islam, Iffat

AU - Refaie, Syed Ahmed

AU - Ali, Tamjid

AU - Uddin, Reaz

AU - Hasan, Mohammad

AU - Naz, Radia

AU - Haseen, Fariha

AU - Islam, Syed Shariful

AU - Clegg, Daniel

AU - Rasker (Hans), Johannes J.

PY - 2021/4/21

Y1 - 2021/4/21

N2 - Introduction: Coronavirus disease (COVID-19) started its journey from Wuhan, China and gradually became a pandemic. COVID-19 often affects the respiratory system, but symptoms may include fatigue, myalgia, arthralgia, arthritis, spine-, and bone pain as presenting complaints. In the present systematic search and review, we aim to highlight the musculoskeletal manifestations during COVID-19. Methods: Using PubMed Central and Google Scholar search engines, we used as key words “muscle pain”, “joint pain”, “body ache”, “fatigue”, in Covid-19 patients. Results: After screening, a total of 76 articles were included following inclusion criteria dated between January 1 and July 1, 2020. All articles were published in English comprising 36558 COVID-19 cases. In cross sectional studies, fatigue was found in 55%, myalgia in 26%, and arthralgia in 20%, respectively. In cohort studies, fatigue was found in 35%, myalgia in 15%, and arthralgia in 5%, respectively. Sporadic case reports also mention back pain, bone pain, myositis and arthritis as presenting symptoms of COVID-19. Discussion: Fatigue was the most frequent musculoskeletal (MSK) manifestion of COVID-19 followed by myalgia and joint pain. The frequency of the different MSK manifestations in COVID-19 may vary widely among different geographic regions. Conclusions: MSK like fatigue, myalgia and arthralgia are frequent symptoms in COVID-19 patients and may vary in different countries.

AB - Introduction: Coronavirus disease (COVID-19) started its journey from Wuhan, China and gradually became a pandemic. COVID-19 often affects the respiratory system, but symptoms may include fatigue, myalgia, arthralgia, arthritis, spine-, and bone pain as presenting complaints. In the present systematic search and review, we aim to highlight the musculoskeletal manifestations during COVID-19. Methods: Using PubMed Central and Google Scholar search engines, we used as key words “muscle pain”, “joint pain”, “body ache”, “fatigue”, in Covid-19 patients. Results: After screening, a total of 76 articles were included following inclusion criteria dated between January 1 and July 1, 2020. All articles were published in English comprising 36558 COVID-19 cases. In cross sectional studies, fatigue was found in 55%, myalgia in 26%, and arthralgia in 20%, respectively. In cohort studies, fatigue was found in 35%, myalgia in 15%, and arthralgia in 5%, respectively. Sporadic case reports also mention back pain, bone pain, myositis and arthritis as presenting symptoms of COVID-19. Discussion: Fatigue was the most frequent musculoskeletal (MSK) manifestion of COVID-19 followed by myalgia and joint pain. The frequency of the different MSK manifestations in COVID-19 may vary widely among different geographic regions. Conclusions: MSK like fatigue, myalgia and arthralgia are frequent symptoms in COVID-19 patients and may vary in different countries.

KW - UT-Gold-D

U2 - 10.22631/rr.2021.69997.1117

DO - 10.22631/rr.2021.69997.1117

M3 - Article

SN - 2476-5856

VL - 6

SP - 59

EP - 80

JO - Rheumatology Research

JF - Rheumatology Research

IS - 2

ER -

Musculoskeletal Manifestations of COVID-19: A Systematic Search and Review

Abstract

Keywords

Access to Document

Fingerprint

Cite this