Nano-ampère stimulation window for cultured neurons on micro-electrode arrays

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    Abstract

    From experiments, it appears to be possible to stimulate a neuron by depolarisation of the lower membrane patch, the sealing part of the membrane, using a nano-ampere current through the extracellular electrode. Also, a stimulation window is observed. These findings can be explained by a finite element model of the neuron-electrode interface which permits geometry based dynamic modeling of the neuron-electrode interface and can be used to explore the requirements for lower membrane stimulation in more detail. An intracellular action potential develops if the current through the lower membrane is able to depolarize the upper membrane sufficiently.
    Original languageUndefined
    Title of host publicationProceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey
    Place of PublicationPiscattaway, USA
    PublisherIEEE
    Pages-
    Number of pages4
    ISBN (Print)0-7803-7213-1
    DOIs
    Publication statusPublished - 25 Oct 2001
    Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001 - Istanbul, Turkey
    Duration: 25 Oct 200128 Oct 2001
    Conference number: 23

    Publication series

    Name
    PublisherIEEE
    Volume1

    Conference

    Conference23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001
    Abbreviated titleEMBC
    CountryTurkey
    CityIstanbul
    Period25/10/0128/10/01

    Keywords

    • IR-42181
    • METIS-200705

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