Nano-ampère stimulation window for cultured neurons on micro-electrode arrays

Jan R. Buitenweg; Wim Rutten; Enrico Marani

doi:10.1109/IEMBS.2001.1019043

Nano-ampère stimulation window for cultured neurons on micro-electrode arrays

Jan R. Buitenweg, Wim Rutten, Enrico Marani

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

58 Downloads (Pure)

Abstract

From experiments, it appears to be possible to stimulate a neuron by depolarisation of the lower membrane patch, the sealing part of the membrane, using a nano-ampere current through the extracellular electrode. Also, a stimulation window is observed. These findings can be explained by a finite element model of the neuron-electrode interface which permits geometry based dynamic modeling of the neuron-electrode interface and can be used to explore the requirements for lower membrane stimulation in more detail. An intracellular action potential develops if the current through the lower membrane is able to depolarize the upper membrane sufficiently.

Original language	Undefined
Title of host publication	Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey
Place of Publication	Piscattaway, USA
Publisher	IEEE
Pages	-
Number of pages	4
ISBN (Print)	0-7803-7213-1
DOIs	https://doi.org/10.1109/IEMBS.2001.1019043
Publication status	Published - 25 Oct 2001
Event	23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001 - Istanbul, Turkey Duration: 25 Oct 2001 → 28 Oct 2001 Conference number: 23

Publication series

Name
Publisher	IEEE
Volume	1

Conference

Conference	23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001
Abbreviated title	EMBC
Country	Turkey
City	Istanbul
Period	25/10/01 → 28/10/01

Keywords

IR-42181
METIS-200705

Access to Document

10.1109/IEMBS.2001.1019043

Nano-ampere_stimulation_-_buitenweg
open

Cite this

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title = "Nano-amp{\`e}re stimulation window for cultured neurons on micro-electrode arrays",

abstract = "From experiments, it appears to be possible to stimulate a neuron by depolarisation of the lower membrane patch, the sealing part of the membrane, using a nano-ampere current through the extracellular electrode. Also, a stimulation window is observed. These findings can be explained by a finite element model of the neuron-electrode interface which permits geometry based dynamic modeling of the neuron-electrode interface and can be used to explore the requirements for lower membrane stimulation in more detail. An intracellular action potential develops if the current through the lower membrane is able to depolarize the upper membrane sufficiently.",

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Buitenweg, JR, Rutten, W & Marani, E 2001, Nano-ampère stimulation window for cultured neurons on micro-electrode arrays. in Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey. IEEE, Piscattaway, USA, pp. -, 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001, Istanbul, Turkey, 25/10/01. https://doi.org/10.1109/IEMBS.2001.1019043

Nano-ampère stimulation window for cultured neurons on micro-electrode arrays. / Buitenweg, Jan R.; Rutten, Wim; Marani, Enrico.

Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey. Piscattaway, USA : IEEE, 2001. p. -.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Nano-ampère stimulation window for cultured neurons on micro-electrode arrays

AU - Buitenweg, Jan R.

AU - Rutten, Wim

AU - Marani, Enrico

N1 - Conference code: 23

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Y1 - 2001/10/25

N2 - From experiments, it appears to be possible to stimulate a neuron by depolarisation of the lower membrane patch, the sealing part of the membrane, using a nano-ampere current through the extracellular electrode. Also, a stimulation window is observed. These findings can be explained by a finite element model of the neuron-electrode interface which permits geometry based dynamic modeling of the neuron-electrode interface and can be used to explore the requirements for lower membrane stimulation in more detail. An intracellular action potential develops if the current through the lower membrane is able to depolarize the upper membrane sufficiently.

AB - From experiments, it appears to be possible to stimulate a neuron by depolarisation of the lower membrane patch, the sealing part of the membrane, using a nano-ampere current through the extracellular electrode. Also, a stimulation window is observed. These findings can be explained by a finite element model of the neuron-electrode interface which permits geometry based dynamic modeling of the neuron-electrode interface and can be used to explore the requirements for lower membrane stimulation in more detail. An intracellular action potential develops if the current through the lower membrane is able to depolarize the upper membrane sufficiently.

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KW - METIS-200705

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DO - 10.1109/IEMBS.2001.1019043

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